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Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.

This study found that in Withdrawal Seizure-Prone mice, ethanol withdrawal decreased the sensitivity of GABA A receptors to GABAergic neurosteroids in certain areas of the brain.

This study found that neonatal administration of finasteride affected adult learning and memory in rats, enhancing object recognition but impairing aversive learning, with no effect on anxiety-like behavior.

In this study, finasteride altered acute ethanol withdrawal severity differently in male and female mice, highlighting sex differences in sensitivity to changes in neurosteroid levels.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study found that neonatal administration of allopregnanolone enhances, while finasteride suppresses, the effects of adult intrahippocampal pregnenolone sulphate on rat locomotor activity in an open field test.

This study found that ethanol-induced deficits in motor coordination in rats are not mediated by elevated neuroactive steroid biosynthesis.

In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.

This study found that finasteride led to increased anxiety-like behavior related to bright spaces in rats, but did not significantly affect open space anxiety-like behavior.

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

This study found that during late pregnancy in rats, there is an increase in extrasynaptic GABA A receptor number in granule cells of the dentate gyrus, linked to hormonal fluctuations.

This study found that neonatal administration of finasteride reduced sensitivity to alcohol's motor-stimulating effects and increased preference for novelty and initial alcohol consumption in rats, suggesting a role in alcohol vulnerability.

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.

This study found that acute finasteride treatment decreased ethanol intake in male C57BL/6J mice, whereas chronic treatment showed diminished effects, implying compensatory changes in neurosteroid modulation.

This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.

This study found that low-dose finasteride treatment in men with premature androgenetic alopecia decreased levels of 5α-reduced steroids, which may be linked to increased depression symptoms.

This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.

This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

This study found that altering neurosteroid levels during early development in male rats can influence KCC2 levels, underscoring the role of neurosteroids in hippocampal maturation.

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

In this study, finasteride-treated WAG/Rij rats showed a significant increase in spike-wave discharges when administered endogenous steroids THPROG and THDOC, indicating potential exacerbation of absence seizures.

This study suggests that altering levels of the neurosteroid allopregnanolone during neonatal stages in rats may impact alcohol consumption and dopamine release in adulthood, indicating potential effects on alcohol reward properties.

This review discusses the potential link between early postnatal allopregnanolone levels and vulnerability to drug abuse in adulthood, noting a need for more in-depth studies to confirm this relationship.

This case report details a rare instance of a young male with coexisting autoimmune polyendocrine syndrome type 2 and anti-GAD65 antibody-associated stiff person syndrome, where symptoms improved by adding intravenous immunoglobulin therapy, emphasizing the importance of awareness for early diagnosis and treatment.

This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.