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The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.

Certain medications can reduce mortality risk in COPD patients, but others can increase risks of cardiovascular issues, postoperative delirium, and other adverse effects.

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Allopregnanolone changes gene expression in glioblastoma cells.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

Tamsulosin increases the risk of floppy iris during eye surgery.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

A reliable method was developed to measure Finasteride and Tadalafil in rat blood.

Finasteride may cause lasting sexual and mental health issues, and genetic screening could help prevent them.

Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

The document explains the difficulty in diagnosing and treating brain diseases caused by the immune system and stresses the need for quick and accurate tests.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Treating both the mind and skin together, especially by managing stress, can greatly improve outcomes for skin disorders linked to psychological issues.

Neonatal allopregnanolone and stress affect behavior differently in adolescence and adulthood.

The interdigital gland of Vembur sheep shows sex-based differences in size and chemical makeup, possibly affecting communication and disease protection.

Finasteride may cause vitiligo, sexual issues, and depression; better treatments and predicting side effects needed.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Using systemic drugs as creams for skin conditions shows promise, but more research is needed to confirm their effectiveness and safety.

Levetiracetam may cause hair loss, which can potentially reverse with lower doses or stopping the drug.

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

Mutations in certain receptors can cause diseases and offer new treatment options.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.