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Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Blood vessels and specific genes help turn cartilage into bone when bones heal.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Lowering testosterone speeds up wound healing in male mice.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

Lower SHBG levels may increase the risk of PCOS.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.