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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

No treatment fully prevents hair loss from chemotherapy yet.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

BMP2 and BMP7 have opposite roles in feather formation.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.