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The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.

This study investigated the effects of cedrol on colorectal cancer and found that it inhibited cell proliferation and induced cell cycle arrest and apoptosis in cell models, while in vivo, it suppressed cancer progression and improved survival at a well-tolerated dose.

This study discovered that a network controlled by the gene p63 is crucial for keratinocyte differentiation and is linked to MYC through cell adhesion-related pathways.

This study found that glibenclamide exhibited a cytostatic effect on MDA-MB-231 breast cancer cells, potentially mediated through K ATP channels, and enhanced the antiproliferative impact of doxorubicin.

WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.

This study found that A(3)B(5) downregulates melanin production and suppresses melanoma cell growth by promoting proteasomal degradation of TRP-2.

This study found that transient inhibition of eIF4E in a transgenic mouse model protected against cyclophosphamide-induced hair loss by inducing cell cycle arrest and reducing cellular apoptosis.

This study found that Danthron induced apoptosis in a human malignant melanoma cell line through mitochondrial, endoplasmic reticulum, and death receptor pathways.

In this study, researchers found that DNMT1-mediated methylation of SRD5A2 in urethral epithelial cells from hypospadias-afflicted rats upregulates proteins associated with cell cycle and mitochondrial function, suggesting SRD5A2 as a potential therapeutic target for hypospadias due to its role in modulating cellular functions.

This study found that prostaglandin D2 reduced proliferation in bulge resident K15+ stem cells but not in other K15+ progenitor cells, suggesting differential impacts on hair follicle stem cell niches.

In this study, researchers found that overexpressing SOX2 in colorectal cancer cell lines can cause DNA damage and cell death, while repressing it reduces tumor growth and cell aggressiveness.

In this study, the ethyl acetate extract of Semecarpus anacardium Linn leaves was reported to induce cytotoxicity in cancer cells, cause cell cycle arrest, and suppress tumor growth in mice.

In this study, researchers found that pregnant mice exposed to excessive androgen led to thinner ventricular walls and cardiac hypertrophy in offspring, suggesting that prenatal androgen exposure adversely affects cardiac health through reduced cardiomyocyte proliferation.

This study observed that CIP/KIP proteins play a significant role in regulating cell cycle arrest and differentiation in human hair follicles, supporting hair growth and formation in the anagen phase.

In this study, XMU-MP-1 unexpectedly reduced cell proliferation and altered cell cycle progression in a model human hair follicle, possibly due to off-target kinase inhibition.

This review reports that the compound Cepharanthine shows promise as a cancer therapy by inducing cell death, arresting cell growth, inhibiting tumor progression, modulating key oncogenic pathways, and reversing multidrug resistance, suggesting its potential for further investigation in oncology.

This study found that ALRN-6924, a clinical-stage dual inhibitor, can selectively protect human scalp hair follicles from paclitaxel-induced toxicity and damage by inducing transient cell cycle arrest in healthy cells without affecting cancer cells, potentially reducing chemotherapy-induced alopecia.

In this study on mice, intensive stress through methods like resiniferatoxin injections and physical restraint was found to inhibit hair follicle growth, with the mechanism involving the sympathetic nervous system and the cAMP signaling pathway in hair follicle stem cells.

This study found similarities in the regeneration processes of MRL mouse ears and axolotl limbs, involving G2 cell cycle arrest and nerve-dependent mitosis, but the role of p21 in axolotl limb regeneration remains uncertain.

This study observed that, in mouse ear epidermal stem cells, a cell-autonomous size control mechanism involving the RB pathway dictates S phase entry timing based on cell size, despite external environmental variations affecting growth rates.

This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.

This study observed that treating basal and squamous cell carcinoma cells with platelet-rich fibrin significantly reduced cell viability and increased apoptosis-associated gene expression, suggesting potential use as adjunctive therapy for localized nonmelanoma skin cancers.

This study found that the transcription factor Gata6 plays a crucial role in adult mouse hair follicle regeneration by promoting the renewal and preventing DNA damage of rapidly proliferating progenitor cells.

This study found that all-trans retinoic acid (ATRA) inhibits proliferation and promotes apoptosis in secondary hair follicle-derived dermal papilla cells from cashmere goats, likely via the TGF-β2/Smad2/3 signaling pathway.

In this study, ethyl acetate fraction of Eclipta alba was found to inhibit adipogenesis and reduce dyslipidemia in hamsters, suggesting potential as an herbal treatment for obesity.

This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.

This study found that the interaction between heat shock protein 90 and lamin A/C is crucial for the growth, migration, and self-aggregation of dermal papilla cells, suggesting a potential role in alopecia areata mechanisms.

This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.

This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.

In a neonatal rat model, this study found that topical CDK2 inhibitors reduced chemotherapy-induced hair loss in 33 to 50% of the animals, suggesting a potential strategy for preventing alopecia in cancer patients.