research Laboratory and Experimental Trichology
The document concludes that the trichogram is a useful tool for diagnosing hair loss and suggests semi-organ cultures for practical trichological research.
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research The Functional Effects for the Prevention and Treatment on Hair Loss from Astringent Persimmon Fruit Extracts
This study observed that applying astringent persimmon fruit extract may significantly enhance hair growth and lengthen the hair in genetically balding Black mice.
research Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome
This study found that spironolactone treatment can normalize endothelial function and improve cholesterol levels in non-obese patients with polycystic ovary syndrome.
research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis
This paper discusses X-linked ichthyosis and its genetic causes, focusing on biochemical pathways and their role in epidermal differentiation and barrier function, but it presents no new clinical findings.
research Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome
This study found that a 6-month treatment with either metformin or rosiglitazone significantly improved endothelial function in young women with PCOS without any one drug being superior.
research Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins
This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.
research Clinicoepidemiological Observational Study of Acquired Alopecias in Females Correlating with Anemia and Thyroid Function
This study observed that telogen effluvium was the most common form of acquired alopecia among females in a semiurban Indian population, with stress and chemical exposure as major exacerbating factors.
research The Function of Zinc in Animal, Plant, and Human Nutrition
This narrative discusses the critical roles of zinc in both biological processes and industrial applications but provides no new research findings.
research Efficacy and safety of 1565-nm non-ablative fractional laser versus long-pulsed 1064-nm Nd:YAG laser in treating enlarged facial pores
In this study, both 1565-nm non-ablative fractional laser and long-pulsed 1064-nm Nd:YAG laser effectively reduced enlarged facial pores, with no significant difference in efficacy and minimal side effects, though the Nd:YAG laser had less severe side effects.
research Experimental Studies of Inner Ear Hair Cell Regeneration.
This study suggests that supporting cells are the origin of regenerated hair cells in the avian basilar papilla, with epidermal growth factor as a potential trigger, and indicates a possibility of hair cell regeneration in mammalian vestibular epithelia.
research Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice
This review summarizes how genetic studies using conditional β-catenin loss- and gain-of-function mice have advanced understanding of canonical Wnt signaling's role in embryonic development, adult stem cell maintenance, and cancer modeling.
research Defective trophoblast function in mice with a targeted mutation of Ets2
Ets2 gene is crucial for placental development in mice.
research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis
In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.
research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth
This study found that the vitamin D receptor in lampreys, which lack bones and hair, binds 1,25-dihydroxyvitamin D3 and may function to induce enzymes for detoxifying substances.
research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting
This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.
research Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation
This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.
research JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
This study found that JunB, a transcription factor, is crucial for maintaining epidermal-pilosebaceous stem cell homeostasis by regulating progenitor cell behavior and preventing sebaceous gland dysfunction.
research Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
This study found that Blimp1+ cells from mice can generate sebaceous gland organoids in vitro, which mimic natural gland traits and may aid in studying acne vulgaris.
research Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice
This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.
research Loss‐of‐function of Endothelin receptor type A results in Oro‐Oto‐Cardiac syndrome
This study identified a novel homozygous EDNRA variant linked to Oro-Oto-Cardiac Syndrome and showed that EDNRA signaling is essential for normal craniofacial and cardiovascular development.
research Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing
In a study on diabetic mice, researchers developed a protein-based hydrogel that leverages zinc ions and the natural compound phellopterin to promote cutaneous nerve regeneration, angiogenesis, and tissue remodeling in diabetic wounds, highlighting its potential for advanced wound therapy.
research Identification of functional circRNAs regulating ovarian follicle development in goats
In this study, researchers found that the novel gene circCFAP20DC enhances the proliferation of goat follicular granulosa cells by activating the RB pathway, facilitating their progression from the G1 to S phase during follicular development.
research External lipid function in ethnic hairs
This study found that African and Caucasian hair contain the most lipids, and depletion of these lipids leads to less water retention and increased water desorption, with Caucasian hair showing improved breaking tenacity after lipid extraction.
research Simultaneous determination of 30 hormones illegally added to anti-ageing functional foods using UPLC-MS/MS coupled with SPE clean-up
This study developed a new method for detecting 30 hormones in anti-aging functional foods, demonstrating good sensitivity and reliability, and identified seven hormones in four out of 14 samples tested.
research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice
In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.
research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway
This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.
research Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
This study used Cisd2 knockout mice models and found that these mice display premature aging characteristics and an increase in dysfunctional neutrophils, suggesting Cisd2's role in calcium homeostasis and neutrophil function via interactions with Calnexin and SERCA.
research ADVANCES IN FUNCTIONAL NEUROSURGERY – MACHINE LEARNING, NEURAL ENGINEERING AND ROBOTICS IN TREATMENT OF NEURODEGENERATIVE DISORDERS
This source reports that clinical trials using advanced Deep Brain Stimulation systems, augmented with AI to integrate kinematic data, eye tracking, and cognitive assessments, show promise in improving diagnostic accuracy and monitoring symptoms for patients with Parkinson's disease.
research IMPAIRMENT OF AUDITORY FUNCTION IN PERSONS WITH TYPE 2 DIABETES MELLITUS DEPENDING ON THE LEVEL OF PERIPHERAL MYELIN PROTEIN
This study observed that patients with type 2 diabetes and sensorineural hearing loss exhibited significantly higher levels of peripheral myelin protein 22, particularly in those with microangiopathies, suggesting demyelinating processes in the auditory system.
research Establishment and Functional Characterization of Immortalized Rabbit Dermal Papilla Cell Lines
This study established the R-7 dermal papilla cell line, which retained essential characteristics of primary cells without undergoing malignant transformation, suggesting its potential for future hair research.