Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.

This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.

This study identified 19 specific genes involved in root hair growth and morphogenesis in Arabidopsis, using a combination of computational and experimental methods.

This review explores the biological functions of vitamin D, highlighting how deficiency may increase the risk of various diseases, but reports no new clinical results.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.

In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.

This article reviews the structure and function of the skin and its importance for understanding skin diseases, without providing new clinical results.

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

This study reports the first keratin gene mutation affecting the tail domain, leading to a unique cytoskeletal abnormality and severe epidermal hyperkeratosis, highlighting the tail domain's critical role in keratin organization.

This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.

This study reports that overexpression of activin in transgenic mice enhances granulation tissue formation during wound healing, highlighting a novel role for activin in cutaneous repair processes.

This study found that the vitamin D receptor in lampreys, which lack bones and hair, binds 1,25-dihydroxyvitamin D3 and may function to induce enzymes for detoxifying substances.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

This study found that labeled galectin-1 binds to specific nuclear sites in human bone marrow stromal cells and keratinocytes, suggesting a role in nuclear function, although only in a small fraction of cells.

This review discusses the plasticity of stem cell populations and their ability to switch between functions for tissue homeostasis and regeneration, emphasizing environmental and hormonal influences, and reports no new results.

This study found that during late pregnancy in rats, there is an increase in extrasynaptic GABA A receptor number in granule cells of the dentate gyrus, linked to hormonal fluctuations.

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

This study found that the mK6alpha and mK6beta genes in mice are regulated differently at the mRNA level, with implications for understanding K6 gene evolution and function in mammals.

This article reviews over 1000 skin diseases affecting patients' quality of life and highlights the importance of understanding skin biology and pathology, but provides no new results.

This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.

This review highlights the efficacy of transdermal testosterone therapy in improving sexual function in women with hypoactive sexual desire disorder, though approved formulations and long-term safety data are limited.

This study found that loss-of-function mutations in the HOXC13 gene cause autosomal-recessive pure hair and nail ectodermal dysplasia, emphasizing its role in hair and nail development.

This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.

This study found that the vitamin D-VDR system is crucial for mineral and bone metabolism post-weaning and identified missense mutations in 1alpha-hydroxylase causing type I rickets.

This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.

This study suggests that the structure and function of mouse melanocytes in the epidermis and hair bulb are influenced by genetic factors and local tissue environment, including hormones and growth factors.

This study found that untreated men with coeliac disease exhibited androgen resistance, potentially linked to sexual dysfunction, which improved as intestinal health improved, a pattern not observed in other chronic illnesses.

This article discusses the structure and function of the skin and its role in skin disease pathophysiology and reports no new research findings.

This narrative review discusses the impact of polycystic ovary syndrome on women's psychological and sexual well-being, highlighting the potential benefits of interdisciplinary treatments and new interventions to improve life satisfaction and coping, but reports no new results.