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research Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase
This research investigated the role of EphA1 in embryonic and adult tissues, generating mouse models suggesting potential links to skin and colon cancer, sepsis, and post-traumatic injury.
research Effect of human hair keratin on the function of rat liver,renal,heart and hematology profile
In this study, injection of hair keratin artificial material into rats did not significantly affect leucocytes or blood plates compared to normal saline, suggesting its histocompatibility.
research Effect of norplant on androgens and sexual function
Norplant implants lower some androgen levels but don't significantly change sexual function.
research Claudin tight junctionwhat's your function? The role of Claudin 6 in epidermal and hair follicle differentiation
This study found that overexpression of Claudin 6 in mice led to incomplete epidermal formation and hair abnormalities, suggesting its crucial role in skin differentiation and hair follicle development.
research [The effect of nizoral on the function of the hypothalamo-hypophyseal-ovarian system in virilism].
This study found that nisoral treatment in patients with hyperandrogenism was associated with restored menstrual cycles and reduced pathological hair growth, along with decreased testosterone and increased estradiol and progesterone levels.
research Reprogramming of human keratinocytes into functional cardiomyocytes
This study found that induced pluripotent stem cells derived from human keratinocytes efficiently differentiated into cardiomyocytes, forming a homogeneous population with cardiac-specific molecular and functional properties, and demonstrated significant cardiac marker expression and spontaneous contraction capabilities over 15 days of differentiation induction.
research Mechanoregulative hydrogel enables scar-reduced and functional healing of infected diabetic mobile wounds
This study developed a novel hydrogel that improved healing in diabetic infected wounds on mobile sites by controlling infection, inflammation, and mechanical stress, promoting skin regeneration without excess scarring.
research Catechins-rich tea extract and its functional properties mitigating hair loss
This study found that a catechins-rich Assam tea extract demonstrated antioxidant effects and hair growth promotion in mice, suggesting its potential as a natural alternative for treating hair loss.
research Skin γδ T cell subsets have distinct functions in alopecia areata 3844
This study identified specific genes upregulated in skin γδ T cells involved in alopecia areata, with findings suggesting these cells contribute to disease pathogenesis through inflammatory and Th1 response mechanisms in mouse and possibly human skin.
research Ultrasound-ActivatedGelMA Hydrogel Loaded with MSC-EVsPromotes Functional Regeneration of Skin Vasculature, Nerves, andAppendages
In this study, researchers developed a novel method using ultrasound stimulation and a hydrogel delivery system to enhance the regenerative effects of stem cell-derived extracellular vesicles on severe skin injuries, resulting in improved healing and hair follicle regeneration in a mouse model.
research Biopharmaceutical Performance of DiluCap: A Line of Functional Excipients Enhancing Dissolution Profiles of Minoxidil, Finasteride, Melatonin, and Naltrexone.
In this study, researchers reported that hardshell capsules using the DiluCap® line of excipients demonstrated varying dissolution profiles under gastrointestinal-simulating conditions, with minoxidil and finasteride showing rapid release and melatonin and naltrexone displaying controlled release, indicating their suitability for different applications in compounding pharmacies.
research Evaluation of Derma Genie™-H001 as a Functional Cosmetic Ingredient for Hair Loss Improvement: Assessing Anti-inflammatory, Antioxidative, Photoprotective, Antiandrogenic, and Hair Growth-Inductive Effects
In this study, Derma Genie™-H001 was shown to reduce inflammation, counteract oxidative and UVB-induced damage, and support hair growth-related gene expression in human dermal papilla cells, suggesting its potential as a functional cosmetic ingredient to alleviate hair loss symptoms.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
This study synthesized new heterocyclic steroid derivatives and reported their promising antiproliferative activity against breast and prostate cancer cell lines, highlighting selectivity and impact on signaling pathways even in cells resistant to certain treatments.
research EFFECT OF MILIACIN ON STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF SKIN APPENDAGES OF C57BL/6 MICE IN AN EXPERIMENTAL MODEL OF ANDROGENETIC ALOPECIA
Miliacin may help prevent hair loss and improve hair growth in mice with a condition similar to human baldness.
research Acupoint injection of metoclopramide on functional dyspepsia clinical observation and nursing experience
In this study, Zusanli acupoint injections of metoclopramide significantly improved dyspeptic symptoms in patients with functional dyspepsia more than oral domperidone, with no adverse reactions in either group.
research Abstract 1489: Basal cell carcinomas express functional indoleamine 2,3-dioxygenase (IDO) which may confer immunoprotection
This study found significant upregulation of IDO-1 and IDO-2 in human basal cell carcinomas, suggesting that IDO production may confer immune privilege characteristics to the tumors, potentially impacting their growth.
research Gene Expression Analysis Reveals Novel Functions of Vitamin D and Glucocorticoids
This study found that vitamin D regulation plays a crucial role in connecting metabolic and cardiovascular conditions, influencing gene expression related to these disorders in both kidney and heart tissues.
research Increased Expression of Zyxin and its Potential Function in Androgenetic Alopecia
This study found increased Zyxin expression in affected hair follicles of androgenetic alopecia patients and suggested its potential role in the condition's pathogenesis and as a therapeutic target.
research Corrigendum to “Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice” Journal of Molecular and Cellular Cardiology 122 (2018) 114–124
This study found that finasteride improved cardiac function and reduced remodeling after myocardial infarction in mice.
research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAAReceptor Function and Seizure Susceptibility
This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
research Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.
research On the effects of testosterone on brain behavioral functions
This review discusses the complex effects of testosterone on the brain, emphasizing sex differences, and reports no clinical results; the authors highlight the inconsistencies in current study findings.
research Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin
This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.
research The role of tight junctions in skin barrier function and dermal absorption
This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
research Vitamin D receptor is essential for normal keratinocyte stem cell function
This study found that absence of the vitamin D receptor in keratinocytes impairs canonical Wnt signaling and leads to alopecia due to defects in keratinocyte stem cells.
research A Systematic Review of Persistent Symptoms and Residual Abnormal Functioning following Acute COVID-19: Ongoing Symptomatic Phase vs. Post-COVID-19 Syndrome
This systematic review reports that fatigue was the most common symptom in both phases of long COVID, with lung function issues more frequent in the ongoing symptomatic phase and psychological burdens like anxiety and depression more prevalent in the post-COVID syndrome phase.
research Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.
research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis
Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
research Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes
This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.