23 citations
,
June 2017 in “Rejuvenation Research” In this study, minoxidil treatment in aged mice increased elastin expression and improved aortic structure and function, suggesting its potential for arterial remodeling in aging.
22 citations
,
February 2004 in “Journal of pediatric gastroenterology and nutrition” This study found that nutritional deficiencies and gastrointestinal abnormalities are uncommon in children with ichthyosis and growth failure, suggesting chronic hypovolemia may be more prevalent in this group.
18 citations
,
July 2021 in “Molecular Medicine Reports” This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.
17 citations
,
January 2023 in “International Journal of Cosmetic Science” In this study, hydrophobic interactions were found to primarily drive deposition on virgin hair, while electrostatic interactions were more significant for bleached hair, highlighting different target moieties for hair conditioning products.
17 citations
,
September 2016 in “Stem cells translational medicine” In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.
16 citations
,
October 2014 in “Cell death and disease” This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.
16 citations
,
August 2007 in “Histopathology” This case report describes a functional adrenocortical oncocytoma that co-secreted testosterone and cortisol.
15 citations
,
March 2020 in “Experimental and Therapeutic Medicine” This review discusses the inflammatory and immunological processes in the skin and reports no new clinical results, highlighting their roles in skin conditions like psoriasis, atopic dermatitis, vitiligo, and pemphigus.
15 citations
,
July 2015 in “Developmental Dynamics” This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.
14 citations
,
March 2022 in “Plant Cell & Environment” In this study, the authors reported that AtRXR3, a phosphorus-inducible DUF506 protein, modulates root hair growth under phosphorus stress by interacting with calmodulin and influencing calcium oscillations.
13 citations
,
August 2018 in “Journal of Molecular and Cellular Cardiology” This study demonstrated that finasteride treatment reduced cardiac dysfunction and hypertrophic remodeling in mice after myocardial infarction, suggesting potential as a therapeutic strategy for heart failure.
13 citations
,
March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
11 citations
,
April 2018 in “Journal of Dermatology” In a randomized study, men treated with dutasteride for androgenetic alopecia experienced sexual adverse events at twice the rate of those on placebo during 24 weeks, but these events were mild, moderate, and resolved after treatment.
11 citations
,
December 2017 in “Orphanet Journal of Rare Diseases” This study found a previously unreported ST14 gene mutation in a patient with ichthyosis-hypotrichosis syndrome, highlighting novel skin and hair characteristics and emphasizing the critical role of the Asp482 amino acid in matriptase activation.
11 citations
,
October 2015 in “Dermatology and therapy” This study found that finasteride use for androgenetic alopecia was not associated with increased sexual dysfunction compared to an age-matched control group.
10 citations
,
September 2024 in “Journal of Nanobiotechnology” This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.
10 citations
,
November 2023 in “Science Immunology” This study found that deleting specific super-enhancer regions in mice affects CD25 expression in a cell type-specific manner, leading to autoimmune alopecia in some cases and revealing distinct regulatory mechanisms for constitutive and inducible expression of CD25.
10 citations
,
September 2022 in “Cellular and Molecular Life Sciences” This review discusses the roles of the transcription factor SOX9 in organ development and maintenance, providing insights into its regulation and diverse functions, but reports no new experimental results.
10 citations
,
April 2022 in “BMJ Open” This study found that lower urinary tract symptoms were linked to reduced functional ability in older adults, with distinct associations for nocturia in men and frequency, urgency, and overactive bladder in women.
9 citations
,
May 2002 in “PubMed” This study demonstrated that mice lacking skin-specific RXRalpha expression developed hair follicle degeneration and alopecia, indicating the importance of RXRalpha/VDR heterodimers in maintaining hair follicle homeostasis.
8 citations
,
December 2024 in “Frontiers in Medicine” In this study, different treatments on ex vivo skin models effectively simulated varying levels of skin damage, demonstrating the value of these models in testing skin repair products and studying how a compromised skin barrier affects viral penetration.
8 citations
,
November 2021 in “Environmental and Experimental Botany” This study found that brassinosteroid enhances kiwifruit root growth by regulating genes involved in auxin signal transduction, highlighting its critical role in root development.
8 citations
,
April 2013 in “Advances in Wound Care” This study found that absence of α3 integrin in mice led to faster wound healing but also caused inflammation, hair loss, and skin defects, suggesting complex roles in skin integrity and repair.
8 citations
,
April 2004 in “The Journal of Urology” Doxazosin and finasteride negatively affect sexual function in men with BPH.
7 citations
,
May 2024 in “Tissue Barriers” The researchers reported that components of keratinocytes influence the formation and differentiation of the stratum corneum, the epidermis's most specialized layer.
7 citations
,
January 2009 in “Biological & pharmaceutical bulletin” This study found that applying ferrous ferric chloride skin lotions to newborn mice stimulated skin cell proliferation and differentiation, increased hair growth, and inhibited alopecia-related hair loss.
7 citations
,
December 2021 in “Journal of Infection” This study found that one in four participants in Chennai, India, reported persistent symptoms 12-14 weeks after COVID-19 recovery, with hospitalization for severe COVID-19 being linked to long-term symptoms.
6 citations
,
July 2024 in “Heliyon” This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.
6 citations
,
March 2009 in “Pigment Cell & Melanoma Research” This study suggests that a purified sphingolipid fraction can activate melanocyte stem cells via p38 signalling, potentially offering a non-UV-based treatment for vitiligo, though additional validation is needed.
5 citations
,
January 2021 in “Frontiers in Cell and Developmental Biology” This study found that elevated expression of the protein Zyxin in hair follicles is associated with androgenetic alopecia and suggests it may be targeted for therapy.