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This review discusses the diverse roles of Frizzled proteins in developmental and homeostatic processes and reports no new experimental findings.

This study developed a potent Wnt surrogate with high specificity for the Fzd7 receptor in mice, promoting full hair follicle regeneration and robust hair growth, suggesting potential applications in tissue development and targeted regeneration.

This study observed that in frizzled 6 null mice, initially uncorrelated hair follicle orientations develop into highly ordered patterns over time, suggesting possible mechanisms for biological structure patterning.

In this study, researchers investigated the impact of a bioactive peptide derived from amphibians on hair follicle regeneration in diabetic skin, focusing on its potential to enhance wound healing and reduce infection risk.

This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.

This study found that intradermal injection of Secreted Frizzled-related Protein 4 inhibits, but does not block, hair follicle regeneration in mice, suggesting potential therapeutic applications for hair follicle regeneration disorders.

This study found that OVOL1-regulated genes, particularly Fst and SFRP1, significantly affect the hair-inducing capacity of neonatal mouse dermal cells.

This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.

This study found that sFRP4 inhibits but does not block hair follicle regeneration in mice, suggesting a potential role in treating hair follicle regeneration disorders.

This study found that injecting sFRP4 into mouse skin partially inhibited hair follicle regeneration, suggesting a potential therapy for hair follicle regeneration disorders.

This study identified a 69 bp deletion in the KRT75 gene as the cause of the frizzle feather trait in chickens, affecting feather curling.

This study observed that the topical skin-whitening agent rhododendrol induced skin depigmentation in approximately 16,000 consumers, linked to melanocyte cytotoxicity and immune reactions.

In this cross-sectional study, researchers found that those without a diabetic background had higher levels of secreted frizzled related protein-4, while family history of diabetes was strongly correlated with waist circumference, waist-to-height ratio, and insulin resistance but not significantly linked to protein-4 levels.

This study reported that baicalin activates the Wnt/β-catenin signaling pathway in mouse hair follicles, suggesting its potential as a topical treatment for hair loss.

This study found that Bimatoprost significantly promotes the growth of reconstructed hair follicles in nude mice by activating the Wnt/β-catenin signaling pathway, with comparable effects to minoxidil.

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.

The Celsr1 gene is crucial for normal hair patterning in mice.

In this study, researchers found that hair follicle orientation in Fz6 −/− mice is disrupted and that hair may reorient itself over time through a self-organized process.

This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.

This study revealed that frizzled 3 can fully rescue polarity defects in frizzled 6-null mice, while frizzled 6 can partially rescue defects in frizzled 3-null mice, highlighting conserved signaling roles in these proteins.

This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

Collagen XVIII is crucial for maintaining tissue structure and function in the brain, kidneys, and hair.

This study reports that extracellular microvesicles isolated from stimulated dermal fibroblasts enhanced hair follicle growth ex vivo and identified norrin as a novel modulator in hair regeneration processes.

This review discusses the role of BMP/Wnt signaling in regulating stem cell homeostasis and activation but reports no new experimental findings.

Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.

This study found that in mice lacking EGFR, elevated Wnt signaling disrupts hair follicle development by affecting cell proliferation and differentiation, revealing a critical role for EGFR in regulating these processes.

This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.

This study found that SFRP2 enhances Wnt3a-mediated β-catenin signaling in human dermal papilla cells, with higher SFRP2 expression in beard cells correlating with increased trichogenicity.

This review examined and discussed the role of dermis-derived factors in the regulation of melanogenesis, noting their significance in both normal and abnormal mammalian skin conditions, suggesting an underexplored area of study compared to dermal and epidermal influences.