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Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

The document concludes that dandruff and seborrheic dermatitis are linked to inflammation and skin changes, and treating them with specific shampoos can reduce these issues.

The yeast Pityrosporum ovale can cause skin allergies and infections, and antifungal treatments like ketoconazole are effective against it.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.

Some Thai plants, especially Carthamus tinctorius, could help prevent hair loss and promote hair growth without adverse effects.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

Folliculitis is an inflammation of hair follicles that requires proper diagnosis and treatment based on the specific cause.