April 2010 in “The journal of immunology/The Journal of immunology” This study found that deleting the FoxN1 gene in mice disrupted the 3D thymic epithelial structure and led to 2D epithelial cysts, revealing its crucial role in thymus organization but not causing athymia.
May 2021 in “Experimental Cell Research” In this study, SFRP1 expression was found to be upregulated in hair follicles from men with androgenetic alopecia, with the transcription factor FOXC1 playing a significant role in its regulation.
6 citations
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April 2017 in “Experimental dermatology” This study found that B6.CD80CD86−/− mice developed autoimmune-like alopecia with nearly 100% incidence by 40 weeks, making them a promising model for studying human alopecia areata.
3 citations
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January 2024 in “Poultry Science” This study demonstrated that FOXO3 influences feather follicle development in goose embryos by regulating the Wnt/β-catenin signaling pathway in dermal fibroblasts, resulting in changes to feather size and structure without altering follicle density.
This study found that distinct hair fiber structures among blue fox, mink, and otter rabbit can be used to identify and differentiate these fur types.
39 citations
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May 2014 in “Frontiers in Pharmacology” In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.
11 citations
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May 1998 in “Acta agriculturæ Scandinavica. Section A, Animal science” This study observed that pelage development in male blue foxes born in early June was more synchronized than those born in early May, with differences likely influenced by melatonin levels.
1 citations
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January 2013 In this study conducted in Ilam province, Iran, researchers found that 19.35% of red foxes and 17.85% of jackals were infested with at least one type of ectoparasite, primarily Ctenocephalides canis.
February 2026 in “Animals” In this study, supplementing low-protein diets with 0.75% methionine maintained growth performance, improved fur quality, enhanced nutrient utilization, and supported intestinal microbiota balance in blue foxes, with significant results on several biochemical parameters and nutrient digestibility observed.
In this study of foxes and jackals in Ilam province, Iran, 19.35% of foxes and 17.85% of jackals were found to be infested with ectoparasites, mainly Ctenocephalides canis.
January 2026 in “Journal of Investigative Dermatology” This study found that human γδTregs promoted hair regrowth and restored hair follicle immune privilege in a model of alopecia areata, suggesting potential for cell-based therapy in autoimmune diseases.
103 citations
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January 2011 in “Blood” This study found that thymus transplantation in infants with FOXN1 deficiency led to T-cell reconstitution and functional immunity, resolving serious infections and cytopenias.
5 citations
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January 2022 in “PloS one” This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.
This study discovered that the transcription factor FoxA is crucial for the regeneration of the planarian pharynx, revealing its new role in organ-specific regeneration.
1 citations
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January 2021 in “Pakistan journal of zoology” This study identified significant differences in medullary structure, hair length, and root diameter among dorsal guard hairs of red foxes, golden jackals, and gray wolves in Turkey.
This case report documents the first instance of Microsporum canis infection in a red fox, successfully treated with ketoconazole, highlighting asymptomatic cats as possible carriers of this pathogen.
This study found that treatment with ivermectin or fluralaner led to complete recovery in 12 of 15 reintroduced red foxes with sarcoptic mange in South Korea, highlighting the importance of ongoing treatment and monitoring.
January 2005 in “Jukuri (Natural Resources Institute Finland (Luke))” This study found that lower dietary protein with supplemented methionine allowed blue foxes to grow normally and produce high-quality pelts while reducing feed costs and environmental phosphorus and nitrogen loads.
13 citations
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December 1940 in “The journal of nutrition/The Journal of nutrition” In this study, silver foxes given a yeast "filtrate factor" supplement retained their fur and normal pelts, while those without it experienced fur loss and thymus abnormalities.
8 citations
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January 2014 in “BioMed Research International” This study reported that among three plant extracts tested for hair growth on nude mice, Eclipta alba significantly increased hair density and length, unlike Asiasari radix and Panax ginseng.
5 citations
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August 2013 in “Integrative Zoology” In this study, adding disinfected feathers to the diet of captive Arctic foxes increased gut bacterial species diversity without changing overall abundance, potentially influencing immune response and physiological performance.
3 citations
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February 1992 in “Journal of veterinary medicine. Series A” This study found that an adult female farm-raised blue fox exhibited an abnormal hair growth cycle and seasonal estradiol variation, with a delayed winter coat cycle resulting in spring shedding.
This study found that a transcription factor called FoxA is specifically required for the regeneration of the planarian pharynx, suggesting its critical role in organ-specific regeneration.
January 2013 in “Heilongjiang xumu shouyi” This study found that a compound additive improved the growth and fur quality of blue foxes, with a 28.7% increase in weight gain and longer pelt lengths compared to the control group.
16 citations
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December 2021 in “Journal of Integrative Neuroscience” This study found that upregulating miR-325-3p in glioma suppresses tumor cell proliferation, migration, and invasion by inhibiting FOXM1, suggesting its potential as a treatment target for brain cancer.
11 citations
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September 2023 in “Nature Communications” In this study, researchers found that the cell surface protein Lrig1 plays a crucial role in regulating the suppressive function of regulatory T cells, suggesting it as a potential target for treating autoimmune diseases, as evidenced by experiments in mouse models.
7 citations
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April 2025 in “Science Advances” This study suggests that a biomaterial-based approach using microneedles and ion solutions to deliver SiO3 2− ions may disrupt inflammatory cycles and improve outcomes in inflammatory dilated cardiomyopathy (iDCM).
305 citations
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December 2000 in “The EMBO Journal” Inhibiting Bmp signaling disrupts hair growth and differentiation.
158 citations
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December 2002 in “Development” In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.
155 citations
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August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.