The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
140 citations,
January 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Liposomes improve drug delivery and reduce skin irritation in dermatology.
130 citations,
August 2020 in “Drug Design Development and Therapy” Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.
69 citations,
June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
47 citations,
April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” The new dutasteride formula can be applied to the skin, may promote hair growth, and has fewer side effects.
47 citations,
November 2012 in “Pharmaceutical research” Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.
45 citations,
August 2011 in “Journal of Microencapsulation” Chitosan microparticles improve minoxidil sulphate delivery, potentially reducing daily applications.
39 citations,
January 2016 in “PubMed” Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
25 citations,
January 2013 in “Journal of Industrial and Engineering Chemistry” Some herbal extracts, especially when used in cubosomal suspensions, were as effective as Minoxidil in promoting hair growth.
22 citations,
October 2019 in “International Journal of Nanomedicine” The nanoparticles improved hair growth and enlarged hair bulbs.
20 citations,
August 2014 in “Therapeutic delivery” The transfollicular route shows promise for noninvasive, targeted drug delivery but needs more research.
19 citations,
December 2013 in “European journal of pharmaceutics and biopharmaceutics” Encapsulated Garcinia mangostana extract in cream penetrates skin better than other forms.
3 citations,
May 2023 in “International Journal of Molecular Sciences” A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.
3 citations,
January 2022 in “Scientific Reports” A new treatment called SAMiRNA-AR68 increases hair count in people with hair loss, showing similar results to existing treatments but without side effects.
The new gel with Zinc Oxide nanoparticles and finasteride shows promise for treating hair loss when applied to the skin.
233 citations,
February 2018 in “Polymers” Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.
96 citations,
April 2017 in “Oncotarget” Smaller nanoemulsions can penetrate skin and hair follicles better, which may be useful for delivering drugs and vaccines through the skin.
68 citations,
March 2018 in “Biomaterials” Tiny needles with valproic acid can effectively regrow hair.
61 citations,
May 2016 in “Scientific reports” The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.
61 citations,
May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
60 citations,
January 2014 in “Anais Brasileiros De Dermatologia” Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.
58 citations,
November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
39 citations,
February 2014 in “European journal of pharmaceutics and biopharmaceutics” Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.
38 citations,
July 2021 in “ACS Nano” Microneedles help treat hair loss by improving hair surroundings and promoting growth.
28 citations,
November 2020 in “Journal of Controlled Release” A new hair loss treatment uses tiny needles to deliver a drug-loaded lipid carrier, promoting hair growth more effectively than current treatments.
23 citations,
January 2018 in “Elsevier eBooks” Nanoemulsions improve stability and delivery of active ingredients in cosmetics for skin and hair care.
21 citations,
December 2016 in “European journal of pharmaceutics and biopharmaceutics” Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.
21 citations,
June 2013 in “European journal of pharmaceutics and biopharmaceutics” The nanoparticle-emulsion with polihexanide is more effective and lasts longer for skin antisepsis.
20 citations,
January 2018 in “Expert opinion on emerging drugs” JAK inhibitors may soon be a safe and effective treatment for alopecia areata.
20 citations,
August 2007 in “Molecular therapy” Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.