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This chapter reviews the hair follicle's role in drug and chemical penetration through the skin but does not present new experimental findings.

In this study, researchers developed isotretinoin-loaded Delonix polymeric nanoparticles that target hair follicles and found they effectively sustained drug release, reduced IL-6 production in vitro without inhibiting P. acnes, and may prevent isotretinoin-related skin irritation in vivo in Wistar rats.

In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.

This review discusses pharmacologic and non-pharmacologic treatments for androgenetic alopecia, noting that current medications like finasteride and minoxidil can slow hair loss but only partially restore hair growth, with early treatment offering better outcomes.

This review discusses the challenges and potential solutions in studying Demodex mites and their possible pathogenic role in human skin disorders but reports no new findings.

The study reported a significant genotype–phenotype correlation in prepubescent males with XLHED, particularly in the severity of skin and hair manifestations between those with different EDA mutations.

This article introduces a new grading system called the FPHL Severity Index to better identify and monitor early stages of female pattern hair loss using clinical criteria.

This article reviews various causes and investigative techniques for different forms of alopecia and reports no new findings.

This study suggests that EDA-A2 induces apoptosis in hair follicles by increasing DKK-1 expression, implicating EDA2R signaling as a potential therapeutic target for androgenetic alopecia.

This narrative review found that while AI-based tools in dermatology, particularly for hair disorder assessment, have potential to enhance clinical practice by improving objectivity and personalization, they currently serve mainly a complementary role and face challenges like methodological limitations and data bias.

This study observed that among male patients who experienced telogen effluvium after platelet-rich plasma treatment for androgenic alopecia, there were elevated levels of TNF-α, androgen receptors, and altered 5α-reductase gene expression, suggesting these factors as potential contributors to this unintended outcome.

This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.

This study found that the M5 isolation method for human dermal papilla cells significantly improved attachment efficiency, proliferative capacity, and trichogenic potential, providing an optimized strategy for scalable manufacturing in hair regeneration therapies for conditions like alopecia.

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.

This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.

This study found that C8/144B antibody exclusively binds to the hair follicle bulge and not the epidermal stratum basale, with cytokeratin 19 serving as a key marker of certain basal keratinocytes that decrease with age.

This pilot study suggests injecting platelet-derived growth factors into the scalp may offer some clinical benefits for androgenetic alopecia, though further randomized trials are needed for confirmation.

This review discusses current knowledge and management strategies for chemotherapy-induced alopecia, highlighting the need for better research prioritization and providing patient support materials, but reports no new clinical results.

This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.

This review discusses the importance of androgen production and metabolism in hyperandrogenism, the use of specific serum markers for diagnosis, and the need for improved assays for clinical testing, but reports no new results.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

This guide reviews the biology of sebaceous glands and their evaluation methods, emphasizing their roles beyond lipid production in skin health and disease, and reports no new research results.

This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.

This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.

The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.

This study found that in androgenetic alopecia, reduced stem cell factor production by dermal papilla cells may lead to decreased pigmentation in hair follicles.

This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.