September 2024 in “Journal of Cutaneous and Aesthetic Surgery” This case report detailed a successful treatment involving contracture release and expanded neck flap reconstruction for a patient with severe neck contracture and beard alopecia from past thermal burns, highlighting improved skin quality and hair regrowth following follicular unit extraction.
January 2025 in “Arquivo Brasileiro de Medicina Veterinária e Zootecnia” In this study, researchers observed that telogen hair was more prevalent than anagen hair in both male and female agoutis over a one-year period in Teresina-PI, regardless of dry or rainy seasons, with no significant differences in dermal follicular volume between the sexes.
107 citations
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May 1999 in “Archives of Dermatological Research” In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.
130 citations
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January 1994 in “Differentiation” In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
2 citations
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January 2019 in “PubMed” This study examined the follicular unit density in the scalp and beard donor areas of Indian men undergoing hair restoration surgery, reporting mean densities of 78.2/cm² and 49.7/cm² respectively, and proposed guidelines for safe follicular unit extraction.
January 2025 in “Revista del Centro Dermatológico Pascua” Early diagnosis and treatment can help manage fibrosing alopecia in older women.
January 2015 in “Journal of Cytology and Histology” This study suggests that follicular stem cells in the bulge region are not directly targeted in androgenetic alopecia, based on the consistent presence of cytokeratin 15 across scalp samples from affected patients.
1010 citations
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August 2000 in “Cell” In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.
June 2024 in “Archives of Plastic Surgery” In this case report, a 44-year-old woman underwent a successful hair transplantation using follicular unit extraction on a myocutaneous free flap, resulting in an 80 to 85% hair survival rate after 12 months and significant improvement in external alopecia aesthetics.
24 citations
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September 2002 in “Dermatologic Surgery” This study describes the anatomy of arrector pili muscles in scalp hair follicular units, proposing a model where a single muscle structure is shared by all follicles within a unit.
10 citations
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July 2017 in “Archives of Plastic Surgery” This study found that hair diameter varies significantly within the occipital safe donor area, with thicker hair in the upper sections and thinner hair in the lower sections.
4 citations
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May 2015 in “Indian Journal of Dermatology, Venereology and Leprology” Congenital triangular alopecia can occur outside the typical fronto-temporal region.
49 citations
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October 2009 in “Cancer research” This study found that disrupting Stat3 in keratinocyte stem cells of mice reduced skin tumor formation by approximately 80%, suggesting Stat3's role in tumor initiation survival mechanisms.
28 citations
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March 2010 in “Histochemistry and Cell Biology” This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.
This case report describes an increase in crown hair coverage using body hair transplantation from the chest and suprapubic regions, suggesting these as viable donor sites but emphasizing the need for standardized patient selection and follow-up.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” The authors concluded that Lrig1-positive stem cells are essential for sebaceous gland formation in mice, as their ablation led to temporary sebaceous gland disappearance without affecting hair growth.
9 citations
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June 2014 in “British Journal of Dermatology” The study found that balding scalps have more thin hairs and larger oil glands, which might contribute to skin conditions related to hair loss.
8 citations
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March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the near-naked hairless mutation in mice is not an allele of the Hairless gene but may involve a mutation in a linked gene or a regulatory mutation.
2 citations
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April 2021 in “International Journal of Pharmaceutics” This study concluded that a liquid serum formulation delivered two fluorescent dyes to deeper follicular regions more effectively than nanoparticle systems.
48 citations
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May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses recent advancements in understanding hair follicles, their disorders, and potential therapeutic opportunities, but it reports no new clinical findings.
9 citations
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November 2004 in “SKINmed Dermatology for the Clinician” This case report describes a 54-year-old man diagnosed with fibrosing alopecia in a pattern distribution, presenting with follicular inflammatory lesions and scleroatrophy on the scalp.
5 citations
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March 2018 in “Dermatologic Surgery” In this study, researchers found all donor sites except the neck region suitable for midfrontal hairline restoration in Southeast Asian women, with donor site hair density and diameter tending to decline with age.
3 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a single application of autologous cellular micrografts showed short-term favorable responses in up to two-thirds of patients with androgenetic alopecia.
2 citations
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May 2018 in “Journal of The American Academy of Dermatology” This study examined 15 female patients with hypothyroidism to investigate the characterization of their alopecia and ruled out other causes, using medical histories, and clinical, trichoscopic, and histologic findings.
2 citations
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July 2018 in “Facial Plastic Surgery” This article discusses how facial plastic surgeons can incorporate hair restoration into their practices and reports no new clinical results.
2 citations
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September 2017 in “Plastic and Aesthetic Research” This study captured digital images of hair regions in healthy individuals and patients with androgenetic alopecia to analyze and compare the number of follicular units and hairs using software.
November 2002 in “Dermatologic Surgery” This review discusses the surgical methods of hair restoration, highlighting the density benefits of scalp reduction and rotation, but reports no new clinical findings.
December 2022 in “Journal of Clinical Medicine” This study reported that a new PRP application protocol with two treatments enhanced hair growth metrics in the vertex region of androgenetic alopecia patients within six months.
54 citations
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January 2009 in “British Journal of Dermatology” This study found that in scarring alopecia, stem cells are differentially localized, suggesting that both inner and outer root sheath stem cells, rather than just follicular bulge stem cells, are involved.
142 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.