January 1992 in “Proceedings of the New Zealand Society of Animal Production” This study observed that key signaling events controlling hair growth in ferret follicles occur between 0 and 4 days after melatonin implantation, highlighting distinct processes in follicular regeneration and fibre growth.
9 citations
,
October 1989 in “Australian Journal of Agricultural Research” This study found that infused mouse epidermal growth factor induced wool follicle involution through a quasi-physiological process similar to catagen and a separate pathological action, resulting in fleece 'break' or shedding.
May 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that treating hair follicular stem cells with tissue extract from 10-day-old mouse embryos significantly enhanced their differentiation into neural cells, particularly with higher extract concentrations.
62 citations
,
September 2014 in “PLoS ONE” This study identified distinct human and bacterial protein profiles in sebaceous follicular casts, with acne samples showing proteins linked to inflammation and normal samples showing proteins involved in stress protection.
292 citations
,
October 1985 in “The Journal of Cell Biology” This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.
2 citations
,
September 2007 This article discusses modern hair restoration surgery techniques, the concept of follicular units, and preoperative evaluation considerations, but it reports no new clinical results.
79 citations
,
November 2010 in “Journal of Neuroscience” In this study, researchers found that simple hair clipping in mice induced dynamic plasticity and axogenesis in skin sensory axons, linked to follicular activation and HGF signaling.
February 2021 in “Journal of The American Academy of Dermatology” This study observed that fibrosis occurs in the bulge region of hair follicles affected by androgenetic alopecia and is correlated with the hair miniaturization process.
January 2024 in “Advanced Healthcare Materials” In a mouse model of androgenetic alopecia, this study developed a treatment combining a copper-curcumin nanoparticle oleogel with traditional Gua Sha therapy, which augmented hair regeneration more effectively than minoxidil by improving the follicular microenvironment and regulation of inflammatory responses.
28 citations
,
March 1973 in “The Journal of Clinical Endocrinology & Metabolism” This study found that hair follicles from balding men show significant metabolic differences compared to those from non-balding individuals, particularly in their ability to process dehydroepiandrosterone.
January 2026 in “European Journal of Dermatology” This study outlines a framework for hair longevity that emphasizes prevention and integrative management of androgenetic alopecia by proposing a multi-targeted approach combining treatments, nutrition, and lifestyle changes.
1113 citations
,
August 1999 in “The New England Journal of Medicine” This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.
98 citations
,
May 2008 in “British Journal of Dermatology” This review discusses evidence-based guidance for managing primary cicatricial alopecias but reports no new clinical results, highlighting significant gaps in knowledge and the need for more quality trials.
55 citations
,
May 2019 in “Journal of Endocrinology” This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.
210 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.
29 citations
,
April 2003 in “Experimental dermatology” In this study, in vitro growth of human hair follicles did not alter hair keratin expression patterns, maintaining follicle integrity and proper keratinization similar to in vivo conditions.
7 citations
,
January 2019 in “Methods in molecular biology” This chapter describes methods for creating engineered skin substitutes with chimeric hair follicles using human and murine cell grafts in immunodeficient mice, but reports no clinical outcomes.
2 citations
,
December 2011 in “[Thesis]. Manchester, UK: The University of Manchester; 2011.” The study suggests that immune privilege collapse in bulge cells and the involvement of pro-inflammatory cytokine interferon-γ contribute to hair follicle stem cell loss in lichen planopilaris.
1 citations
,
July 2020 in “Revista Cereus” This study highlights microneedling as a safe and effective technique for treating androgenetic alopecia in men by permeating active agents, stimulating collagen, and enhancing angiogenesis, which may improve hair growth by activating cellular division and growth.
September 2016 in “Journal of Dermatological Science” This study found that extracellular factors from a specific developmental stage can promote hair follicle neogenesis in adult skin by facilitating interactions between fibroblasts and keratinocytes.
May 2025 in “Cellular Signalling” Oxidative stress and mitophagy play key roles in hair loss, suggesting potential treatment targets.
February 2026 in “Nature Communications” This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that targeting the tumor stroma to promote the formation of dermal condensates may offer a novel approach to treating basal cell carcinoma.
January 2018 in “Elsevier eBooks” The document concludes that proper diagnosis and treatment of follicular disorders are crucial, with specific treatments for conditions like acne, drug-induced eruptions, and rosacea.
40 citations
,
March 2019 in “Nature Communications” This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
17 citations
,
May 2015 in “Aesthetic Plastic Surgery” FUE hair transplantation using a micromotor is effective and gives natural results with few complications.
15 citations
,
January 2013 in “Journal of Cutaneous and Aesthetic Surgery” This study observed that direct hair transplantation, as a modification of follicular unit extraction, was effective in improving baldness in the majority of treated male patients.
16 citations
,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.
45 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article reviews factors affecting follicular unit extraction, emphasizing the need to tailor procedures to individual patient characteristics, but reports no new experimental findings.
8 citations
,
February 1994 in “Archives of Dermatology” This article discusses the challenges in differentiating between basaloid follicular hamartoma and infundibulocytic basal cell carcinoma, highlighting the need for clarity in diagnosis but reports no new results.