February 2018 in “Dermatologic Surgery” Nonshaven follicular unit extraction is a highly satisfactory method for restoring pubic hair.
January 2008 in “Journal of Clinical Dermatology” Integrin alpha-6 and p63 proteins may play a role in hair loss and are important for hair growth and maintenance.
173 citations,
July 1995 in “Biochemical and biophysical research communications” Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
127 citations,
June 2006 in “International Journal of Pharmaceutics” Liposomes and niosomes improve finasteride delivery for hair loss treatment.
88 citations,
August 1998 in “Carcinogenesis” The study demonstrated that elevated levels of ornithine decarboxylase (ODC) and polyamines, when combined with a mutant Ha-ras gene, led to spontaneous tumor development in double transgenic mice. These mice, which were bred to carry both K6/ODC and v-Ha-ras transgenes, developed well-differentiated keratoacanthomas, some of which progressed to carcinomas within 2 months. The tumor development was dependent on ODC, as the use of the ODC inhibitor DFMO prevented tumor formation and caused regression. This indicated that ODC overexpression and activated Ha-ras were sufficient for malignant transformation, providing a model to study epithelial tumor development without chemical carcinogens or tumor promoters.
66 citations,
May 2012 in “Scientific Reports” Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.
47 citations,
November 2012 in “Pharmaceutical research” Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.
42 citations,
July 2015 in “Drug Development and Industrial Pharmacy” Flutamide, delivered by solid lipid nanoparticles, could potentially treat hair loss.
39 citations,
November 2016 in “Pharmaceutics” The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.
39 citations,
October 2013 in “Plastic and Reconstructive Surgery” Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.
38 citations,
September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology” A mutation in mice causes hair loss and skin issues due to a defect in a gene affecting cell adhesion.
32 citations,
January 2012 in “Clinical & Developmental Immunology” Targeting CD200 could be a new treatment for rheumatoid arthritis.
21 citations,
January 2010 in “Skin pharmacology and physiology” Special creams can significantly reduce pollen allergens getting into hair follicles.
15 citations,
July 2017 in “PubMed” Injecting a mix of human skin and hair cells into mice can grow new hair.
15 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Retinoids can change the hair growth cycle by extending the growth phase and shortening the rest phase.
11 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 10 citations,
August 2015 in “Journal of biophotonics” Hair follicles help substances penetrate the skin faster and more effectively.
9 citations,
June 2021 in “International Journal of Pharmaceutics” Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.
8 citations,
October 2018 in “Dermatologic Therapy” About 41% of Indian hair loss patients have low enzyme activity that affects hair loss treatment effectiveness, with men affected more than women. Testing for this can guide treatment.
7 citations,
September 2006 in “Clinical lymphoma & myeloma” Balancing treatment effectiveness with side effects is crucial for relapsed follicular non-Hodgkin's lymphoma, especially in older patients.
6 citations,
October 2013 in “Plastic and Reconstructive Surgery – Global Open” HSL treatment speeds up hair growth and reduces oxidative stress in hair follicles of ob/ob mice.
4 citations,
January 2015 in “Experimental Dermatology” Human hair follicle dermal cells can help repair damaged hair follicles.
3 citations,
February 2021 in “Journal of Cosmetic Dermatology” Long hair FUE, a hair transplant without shaving, is becoming more popular and surgeons should learn it.
3 citations,
September 2016 in “Hair transplant forum international” To avoid damaging hair follicles during strip harvesting, use a specific technique.
2 citations,
May 2012 in “Indian drugs” Finasteride, a hair loss treatment, works better and is more stable when delivered through specially prepared gels, leading to increased hair growth.
2 citations,
January 2012 in “Journal of Cutaneous Pathology” The author clarifies that alopecia areata incognito and diffuse alopecia areata are different types of hair loss with unique symptoms and challenges in diagnosis.
1 citations,
May 2021 in “International Journal of Dermatology” Long hair follicular unit excision is effective for hair transplants, providing quick, natural-looking results with less pain but needs more time, staff, and skill.
1 citations,
July 2016 in “Dermatologic surgery” November 2024 in “Stem Cell Research & Therapy” The study investigates the effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on hair growth in androgenetic alopecia (AGA) model mice. Intradermal transplantation of hUCMSCs in these mice resulted in increased hair growth, hair follicle density, skin thickness, and activation of the anagen phase, while reducing apoptosis in dermal papilla cells (DPCs) and promoting hair follicle stem cell (HFSC) proliferation. The mechanism involves the activation of the Wnt/β-catenin signaling pathway in DPCs, which is crucial for hair regeneration. Blocking β-catenin degradation led to increased DPC apoptosis and reduced HFSC proliferation, highlighting the importance of this pathway in the therapeutic effects of hUCMSCs on AGA.
November 2024 in “BMC Surgery” The document discusses the rising incidence of male androgenetic alopecia and highlights the growing acceptance of follicular unit extraction (FUE) as a suitable treatment method. FUE is a hair transplantation technique that is gaining popularity due to its effectiveness in addressing hair loss in men. The document emphasizes the increasing trend of using FUE to treat this condition, suggesting its potential as a preferred option for individuals experiencing male pattern baldness.