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    Glossary Follicular Keratinocytes

    specialized cells in hair follicles producing keratin for hair

    Follicular keratinocytes are specialized cells found in hair follicles, the structures in the skin that produce hair. These cells are responsible for producing keratin, a protein that forms the structural foundation of hair. They play a crucial role in the growth and health of hair by continuously dividing and differentiating to form the hair shaft.

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    1. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells Development · 2006 · 207 citations
    2. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    3. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    4. Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle Experimental Dermatology · 2003 · 55 citations
    5. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    6. The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011 · 24 citations
    7. Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients 2016 · 19 citations
    8. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    9. Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes Frontiers in Cell and Developmental Biology · 2020 · 5 citations
    10. Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells Experimental Dermatology · 2012 · 6 citations
    11. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    12. Hair Growth Promoting Effects of Kesh-Kanti-Expert-Oil are Mediated Through Keratinocyte Proliferation and Modulation in Follicular Microenvironment Pharmacological Research - Natural Products · 2025
    13. Restoration of hair-inductive activity of cultured human follicular keratinocytes by co-culturing with dermal papilla cells Biochemical and Biophysical Research Communications · 2018 · 14 citations
    14. Exosomes derived from uMSCs promote hair regrowth in alopecia areata through accelerating human hair follicular keratinocyte proliferation and migration Cell Biology International · 2023
    15. No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles Experimental Dermatology · 2018 · 7 citations
    16. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    17. Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth Journal of Investigative Dermatology · 1992 · 9 citations
    18. Culture of hair matrix and follicular keratinocytes Journal of Investigative Dermatology · 1993 · 26 citations
    19. Proliferation and differentiation of cultured human follicular keratinocytes are not influenced by biotin Archives of Dermatological Research · 1995 · 4 citations
    20. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells Nutrients · 2019 · 13 citations
    21. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    22. ABSENCE OF H2O2 BREAKDOWN IN HUMAN HAIR MEDULLA IMPLICATIONS IN FOLLICULAR MELANOGENESIS International journal of research - granthaalayah · 2018 · 1 citations
    23. Effects of Platelet-Rich Plasma on Hair Growth using Artificial Intelligence-based Trichoscopy and Ki67+ Keratinocytes Analysis: A Randomized Placebo-Controlled Trial Clinical Dermatology Review · 2025
    24. EVALUATION OF EFFICACY OF FOLLICULAR UNIT EXCISION VERSUS FOLLICULAR UNIT EXCISION WITH NANOFAT IN SCARS IN HAIRY AREAS ALEXMED ePosters · 2025
    25. 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation 2023
    26. Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice International Journal of Molecular Medicine · 2014 · 24 citations
    27. Follicular mucinosis: A detailed morphologic and immunopathologic study Journal of the American Academy of Dermatology · 1984 · 51 citations
    28. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017 · 42 citations
    29. Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers Biomaterials · 2013 · 40 citations
    30. Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss Seminars in Plastic Surgery · 2005 · 13 citations