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    Glossary Follicular Hyperkeratinization

    overproduction of keratin blocks hair follicles, causing inflammation

    Follicular Hyperkeratinization is a condition where the skin cells around hair follicles produce too much keratin, a protein that helps form the outer layer of the skin. This excess keratin can block hair follicles, leading to issues like acne or folliculitis, where the follicles become inflamed.

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    1. 671 Impaired follicular Nrf2 signaling: Potential early therapeutic target in hidradenitis suppurativa 2022
    2. No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles Experimental Dermatology · 2018 · 7 citations
    3. ACNE Dermatologic Clinics · 1997 · 58 citations
    4. Adult female acne: Clinical and therapeutic particularities (Review) Experimental and Therapeutic Medicine · 2021 · 4 citations
    5. Assessment of efficacy and safety of dapsone gel 5% in the treatment of acne vulgaris مجله كليه طب الكندي · 2019 · 1 citations
    6. Anais Congresso Nacional Sobre Obesidade e Síndrome Metabólica Scire Salutis · 2025
    7. A review on nutracosmetic for skin care International Journal of Pharmacognosy and Pharmaceutical Sciences · 2025
    8. Histomorphological changes of the skin and hair follicles caused by different diseases in dogs with alopecia Lithuanian University of Health Sciences · 2016
    9. Acne Vulgaris InTech eBooks · 2017
    10. Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis British Journal of Dermatology · 1997 · 12 citations
    11. Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes Scientific Reports · 2023 · 16 citations
    12. Erythromelanosis Follicularis Faciei et Colli: A Case Report International Journal of Drug Delivery Technology · 2026
    13. Polycystic Ovary Syndrome-Associated Acne: The Interplay of Hyperandrogenism, Insulin Resistance, and Therapeutic Strategies Cureus · 2025
    14. Acne and acneiform eruptions Elsevier eBooks · 2011 · 2 citations
    15. The Significance of Scalp Involvement in Pemphigus: A Literature Review BioMed Research International · 2018 · 13 citations
    16. Pathways to inflammation: acne pathophysiology European Journal of Dermatology · 2011 · 68 citations
    17. Role of insulin resistance and diet in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 39 citations
    18. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis Dermatology and Therapy · 2021 · 78 citations
    19. The evolution of healthy skin to acne lesions: a longitudinal, <i>in vivo</i> evaluation with reflectance confocal microscopy and optical coherence tomography Journal of the European Academy of Dermatology and Venereology · 2019 · 19 citations
    20. 5-Bromo-2′-deoxyuridine induced effluvium via p53-mediated CD326-positive keratinocyte apoptosis in C57BL/6 mice Journal of Dermatology · 2016
    21. Meibomian gland changes in the rhino (hrrhhrrh) mouse. PubMed · 1988 · 48 citations
    22. Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology Experimental dermatology · 2023 · 2 citations
    23. Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency ˜The œAmerican journal of pathology · 2015 · 23 citations
    24. Acne-Associated Syndromes InTech eBooks · 2017 · 1 citations
    25. A Comprehensive Review: The Bidirectional Role of Sebum in Skin Health Bioengineering · 2025
    26. Saponins of Paris polyphylla for the Improvement of Acne: Anti-Inflammatory, Antibacterial, Antioxidant and Immunomodulatory Effects 2024
    27. Acne Syndromes and Mosaicism Biomedicines · 2021 · 1 citations
    28. Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp Journal of Cutaneous Pathology · 2017 · 9 citations
    29. Role of skin microbiome and exosomes in Hair regeneration and disorders in diseases like Alopecia, Acne: A comprehensive review International Journal of Web of Multidisciplinary Studies · 2026
    30. Lymphocytic mediated alopecia: histological classification by pattern analysis Clinics in Dermatology · 2001 · 29 citations