December 2025 in “International Journal of Research in Dermatology” This study observed that keratosis pilaris is the most prevalent follicular keratotic disease, especially in adolescent and young adult females, and emphasized the key role of dermoscopy and histopathology in distinguishing it from other similar disorders and aiding in diagnosis.
18 citations
,
October 2002 in “Veterinary dermatology” This study observed that follicular dysplasia in Weimar Pointers produces histopathological features and hair abnormalities similar to color dilution alopecia, though less severe.
September 2023 in “JEADV Clinical Practice” This study identified key dermoscopic features in folliculotropic mycosis fungoides patients, showing that dilation of follicular openings and spiky follicular keratosis are specific indicators of follicular involvement, potentially aiding in diagnosis, classification, and treatment decisions.
16 citations
,
July 2018 in “Experimental Dermatology” This study suggests that the transcription factor Gata6 plays a role in maintaining the structure of the upper hair follicle and may be implicated in conditions marked by its abnormal expansion, such as acne or cystic diseases.
This study observed that long-term laser hair removal in women may alter hair follicle structures and stem cell interactions, with dermal fibrosis potentially influencing hair regrowth prevention.
January 2023 in “Pesquisa Veterinária Brasileira” This study reports that hypotrichosis congenita in Hereford cattle is associated with a KRT71 mutation, leading to color dilution follicular dysplasia.
January 2016 in “Lithuanian University of Health Sciences” This study in a Lithuanian veterinary clinic observed diverse histomorphological skin changes in alopecic dogs caused by various rare diseases, including hyperkeratinization and pigmentation disorders.
1 citations
,
January 2006 in “Elsevier eBooks” The conclusion is that different types of hair loss in dogs and cats can be cosmetic or serious, and affected animals should not be bred.
6 citations
,
September 2014 in “Journal of the American Academy of Dermatology” In this report, researchers described a potential new variant of mucinous nevus, characterized by dilation of hair follicle pores and fibromucinous stroma in both the papillary and perifollicular dermis.
January 2016 in “Springer eBooks” This review discusses the potential of superficial cryotherapy as an effective and safe treatment for alopecia areata in eyebrows, with a proposed mechanism involving improved follicular nutrition, but reports no new clinical results.
1 citations
,
February 2018 in “Plastic and Aesthetic Research” This article describes a new instrument, the KD spreader, designed to help novice physicians perform follicular unit extraction hair transplantation with reduced trauma and operator fatigue, but it does not report new clinical results.
32 citations
,
February 2008 in “Journal of the American Academy of Dermatology” This case report describes a family with autosomal dominant transmission of keratosis follicularis spinulosa decalvans, with observed treatment refractoriness in multiple topical and systemic therapies.
25 citations
,
June 2015 in “Clinical, Cosmetic and Investigational Dermatology” This study found that using an electrical microneedling device enhanced the penetration of liposomal melanin-fluorescein into hair structures and widened the follicular infundibulum in ex vivo human skin models.
316 citations
,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.
211 citations
,
February 2009 in “European journal of pharmaceutics and biopharmaceutics” This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.
171 citations
,
July 2007 in “Journal of Investigative Dermatology” The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.
89 citations
,
November 2014 in “International Journal of Nanomedicine” This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.
69 citations
,
September 2006 in “Human Reproduction” This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.
40 citations
,
March 2019 in “Nature Communications” This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
35 citations
,
October 2015 in “International Journal of Pharmaceutics” Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.
19 citations
,
July 2020 in “Journal of drug delivery science and technology” This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.
13 citations
,
December 2019 in “Nutrients” In human follicular cells, this study found that an Annurca apple-based dietary supplement may stimulate the production of hair keratins, suggesting potential benefits for hair growth.
10 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified FP-1 as a highly specific extracellular matrix protein in follicular papilla cells, which may play a role in hair growth regulation during specific hair cycle phases.
9 citations
,
July 2017 in “Journal of Drug Delivery Science and Technology” This study suggests that a microemulsion formulation of Minoxidil effectively enhances drug delivery through hair follicles, showing significant follicular response alterations in an alopecia model.
9 citations
,
June 2003 in “Veterinary dermatology” This study describes recurrent or persistent follicular dysplasia and interface dermatitis in Boxers, noting concurrent courses and potential influences from photoperiod or genetics, but without identifying the condition's exact causes.
8 citations
,
February 2016 in “The American Journal of Dermatopathology” In this study, the researchers found that transplanted hair follicles undergo significant morphological changes, including a thickened dermal sheath and increased hair shaft diameter, which are associated with altered follicular vascularization.
8 citations
,
January 2014 in “Annals of Dermatology” This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.
6 citations
,
July 2019 in “Journal of Cosmetic Dermatology” In this study, the researchers reported that the hair transection rate during FUE surgery increased significantly by the end of the procedure, suggesting a higher workload affects the surgeon's performance.
5 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” This study found that the trichogenicity of cultured human outer root sheath follicular keratinocytes decreased with longer cultivation periods and was significantly influenced by the expression of the transcription factor FOXA2.
4 citations
,
September 2019 in “Journal of Cosmetic Dermatology” This study found that follicular unit extraction megasession resulted in high patient satisfaction without infections for treating severe androgenetic alopecia, offering a promising one-stage option compared to multi-stage hair transplants.