28 citations
,
November 1987 in “Journal of the American Academy of Dermatology” This study developed an in vitro model using human follicular keratinocytes to observe selective cell growth and differentiation, potentially aiding future research on hair biology and growth processes.
28 citations
,
October 1985 in “The Journal of Cell Biology” This study identified two types of hard alpha-keratin filament assemblies in developing human hair follicles, which may help investigate the structural framework of mammalian keratin appendages.
28 citations
,
March 1973 in “The Journal of Clinical Endocrinology & Metabolism” This study found that hair follicles from balding men show significant metabolic differences compared to those from non-balding individuals, particularly in their ability to process dehydroepiandrosterone.
27 citations
,
August 2021 in “Journal of Autoimmunity” This study found that human dermal γδT-cells can act as stress sentinels and potentially trigger autoimmune responses toward stressed hair follicles, resembling features of alopecia areata.
27 citations
,
October 2020 in “Biomedicine & Pharmacotherapy” This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.
27 citations
,
April 2020 in “PLoS ONE” In this study, RNA-Seq analysis identified 2717 genes differentially expressed between anagen and telogen hair follicle stem cells in cashmere goats, potentially involving several signaling pathways in vitro.
27 citations
,
March 2018 in “Biomaterials” This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.
27 citations
,
June 2015 in “Journal of photochemistry and photobiology. B, Biology” This study reported that sunscreen with SPF50+ provides a high level of DNA protection against UV-induced damage in a reconstituted human epidermis model, comparable to that in skin explants.
27 citations
,
June 2013 in “Genes & development” This study found that L-type channel blockers can induce hair growth in Timothy syndrome by overcoming delays in anagen phase, suggesting a potential therapeutic role for tissue regeneration.
27 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified somatostatin as a potential secretory factor contributing to the immune privilege of human hair follicles.
27 citations
,
May 2011 in “Journal of Investigative Dermatology” TCHHL1 is a protein important for hair growth, found in hair follicles.
27 citations
,
January 2010 in “Animal” In these studies, researchers found that Peruvian camelids reach mature skin follicle development early, with specific cuticular characteristics useful for distinguishing fleece types, while Bolivian llamas have a mature follicle apparatus present at birth.
27 citations
,
May 2006 in “Biochemical and Biophysical Research Communications” In this study, Wnt-10b was found to promote hair follicle development and hair growth in cultured mouse embryonic skin and transplanted skin in nude mice.
27 citations
,
January 2006 in “Colloids and Surfaces B: Biointerfaces” This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.
27 citations
,
November 2005 in “Archives of Dermatological Research” This study found that selecting human hair follicles at a defined anagen stage based on their in vivo growth rate leads to more consistent results in organ culture, with minoxidil significantly enhancing hair growth in these follicles.
27 citations
,
December 2002 in “Journal of dermatological science” This study demonstrated a close anatomical relationship between Merkel cells and Langerhans cells in human hair follicles, suggesting potential functional interactions in the bulge area.
27 citations
,
June 2001 in “International Journal of Dermatology” This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.
27 citations
,
October 1998 in “Differentiation” Basonuclin helps identify and track hair follicle development and cycling in mice.
27 citations
,
December 1997 in “Archives of Dermatological Research” This study observed that cultured dermal papilla cells showed distinct functional properties from dermal fibroblasts, including lower proliferation rates, higher adhesion to collagen type IV, and different cell-matrix interactions.
27 citations
,
September 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that relatively low concentrations of 1,25(OH)2D3 stimulated human hair follicle and fiber growth, while higher concentrations inhibited growth in a whole-organ culture system.
27 citations
,
November 2012 in “Journal of Biomedical Optics” This study used confocal Raman microscopy to confirm optical similarity between human and porcine hair follicles, supporting its use in assessing trans-follicular drug delivery.
26 citations
,
February 2020 in “International Journal of Biological Macromolecules” This study demonstrates that massage significantly enhances the follicular targeting of dutasteride-loaded nanocapsules, increasing drug accumulation in hair follicles by up to 5 times.
26 citations
,
August 2019 in “Stem Cell Research & Therapy” This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.
26 citations
,
May 2019 in “PLOS ONE” This study observed that hair follicles in hair loss patients had increased levels of Propionibacterium acnes, potentially linked to elevated immune response gene expression in miniaturized hair follicles.
26 citations
,
January 2019 in “Experimental Dermatology” This study developed an in vitro system to analyze human skin progenitor cells' ability to form hair peg-like structures, providing insights for engineering hair follicle organoids.
26 citations
,
September 2018 in “Journal of Molecular Cell Biology” This study observed that Endoglin is crucial for maintaining correct hair follicle cycling and stimulating hair follicle stem cell niches through feedback interactions involving Wnt/β-catenin and Bmp/Smad signaling pathways in a mouse model.
26 citations
,
September 2018 in “Colloids and Surfaces B: Biointerfaces” This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.
26 citations
,
January 2013 in “BioMed Research International” This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
26 citations
,
February 2012 in “Journal of Investigative Dermatology” This study found that dermal papilla cells from human hair follicles can be reprogrammed into induced pluripotent stem cells, but their efficiency is similar to that of fibroblasts, unlike in mice.
26 citations
,
April 2011 in “Skin Research and Technology” This study found that in vivo confocal scanning laser microscopy accurately quantifies neogenic hair follicles in mice, producing results similar to histology while avoiding fixation artifacts.