research Current Genetics in Hair Diseases
Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.
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research Nevoid basal carcinoma syndrome (Gorlin syndrome) and pronounced androgenic alopecia in a woman with a novel mutation p.Leu1159fsx32 in the PTCH gene
This letter reports a woman with nevoid basal carcinoma syndrome and pronounced androgenic alopecia associated with a novel PTCH gene mutation p.Leu1159fsx32, suggesting a genetic link in this case study.
research The Hair Growth Effect of Polygoni mulitiflori Radix Water Extracts in C57BL/6 Mice
This study found that Polygoni multiflori Radix water extracts accelerated hair regrowth and hair follicle development in mice, showing a safer profile compared to minoxidil.
research The “Bald Mill Hill” Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR bmh Protein
The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.
research Zwischen Tradition und Innovation Historische Plätze in der Bundesrepublik Deutschland nach 1945
This review discusses epithelial-mesenchymal interactions in hair follicle development and their regulation by molecular signals, but reports no new results; the authors emphasize the need for further research to apply these findings clinically.
research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways
In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.
research Citrus limon-Derived Extracellular Vesicles Promote Hair Growth
Lemon-derived vesicles may help hair grow.
research DKK4 as a novel candidate marker for Zhexi Angora rabbit wool quality
This study found that overexpression and knockdown of DKK4 influence genes involved in hair follicle growth and development in Angora rabbits and identified specific SNPs in DKK4 associated with wool quality, notably showing that the TT/GG haplotype combination relates to higher fibre diameters.
research Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro
This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.
research The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice
This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.
research Special Issue “Molecular Insights into Hair Regeneration”
Understanding molecular signals and genetics is key to improving hair regeneration therapies.
research Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep
In this study on fine-wool sheep, researchers found that overexpressing the TGFBR1 gene decreased proliferation of dermal papilla cells by influencing multiple signaling pathways, suggesting TGFBR1 as a negative regulator in hair follicle development.
research miR-200a Targets PITX2 to Mediate Goose Fibroblast Proliferation Through the Wnt Pathway
This study explored the genetic regulation of goose feather follicle development, identifying miR-200a as a key regulator that inhibits GEDF proliferation through the Wnt pathway, potentially impacting goose down quality and supporting selective breeding strategies.
research Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro
This study found that human dermal papilla cells are surrounded by a basement membrane-like extracellular matrix, which maintains their aggregated structure without strong cell‒cell contacts.
research Hair regeneration: Mechano-activation and related therapeutic approaches.
This review discusses recent advances in hair regeneration strategies, including mechanical stimulation and complementary therapies like MSC transplantation and platelet-rich plasma, and reports no new clinical results.
research Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis
This study highlighted the effectiveness of HT-scCAT-seq as a tool for understanding gene regulation in single cells, offering insights into embryonic skin development and proposing a framework for exploring regulatory mechanisms in various biological and disease contexts.
research Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes
This study found that exosomes derived from mesenchymal stem cells primed with rapamycin significantly enhanced hair regrowth, hair density, and hair follicle development in depilation-induced mice compared to controls, suggesting a potential therapeutic approach for hair loss.
research Molecular mechanisms underlying cashmere quality differences between Jiangnan cashmere goats and Changthangi pashmina goats
This study investigated the genetic factors influencing cashmere quality differences between Jiangnan cashmere goats and Changthangi pashmina goats, identifying 4,942 differentially expressed genes and highlighting 24 key genes related to hair follicle development and cashmere fiber formation.
research Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree
This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.
research Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells.
This study found that exosomes derived from human umbilical cord mesenchymal stem cells effectively promoted growth in human hair dermal papilla cells, implicating the PI3K and Akt pathways as potential targets for treating hair loss.
research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
This review discusses how dysregulated levels of eicosanoids, which are metabolites of phospholipids, may contribute to skin diseases like psoriasis and atopic dermatitis, suggesting the importance of targeted eicosanoid control in diagnosis and treatment.
research Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule
In this study, fibroblasts treated with the small molecule peficitinib were reprogrammed into dermal papilla cell-like cells capable of inducing hair growth, offering a new strategy for hair loss treatment.
research Mixture of Mastic Gum and Peppermint Extracts Promotes Hair Growth and Health in Vitro and in C57BL/6 Mice
The study found that a novel mixture of mastic gum and peppermint extract increased hair growth and gloss in C57BL/6 mice, showing potential as a botanical alternative for promoting hair health.
research pH-Responsive Hydrogel with Dual-crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing
In this study, a new pH-responsive hydrogel composed of polyvinyl alcohol and boric acid was found to release salvianolic acid B effectively, reducing excessive scar formation and enhancing tissue regeneration during early-stage wound healing.
research Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveal Wool Quality-Associated Key Genes in Zhexi Angora Rabbits
In this study of Zhexi Angora rabbits, researchers found that the fine-wool group exhibited lower fiber diameters and a higher hair follicle density than the coarse-wool group, and they identified key candidate genes potentially regulating wool quality through RNA-seq and genome resequencing techniques.
research Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway
This study found that umbilical cord mesenchymal stem cell-derived exosomes improved hair growth in mice with androgenetic alopecia by promoting hair follicle stem cell stemness through the RAS/ERK pathway, suggesting a potential new treatment strategy for this condition.
research CRABP1 Enhances the Proliferation of the Dermal Papilla Cells of Hu Sheep through the Wnt/β-catenin Pathway
This study found that overexpressing CRABP1 in dermal papilla cells promotes their proliferation and influences key genes in the Wnt/β-catenin signaling pathway, which may offer insights into mechanisms controlling hair follicle development.
research Unlocking the potential of the secretome in hair growth enhancement
This literature review examined research on hair follicle biology and hair loss treatments, highlighting the potential of secretome-based therapies, which may enhance hair regeneration and address limitations of treatments like minoxidil and finasteride.
research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration
This study found that topical application of TGF-β mimic promoted enhanced wound healing and tissue regeneration in mice, suggesting its potential as a therapeutic option for improving wound healing.
research Review of Stem Cell Therapy for Hair Loss
This study reviews the potential of stem cell-based therapies, including transplants and exosome treatments, to reactivate hair follicle stem cells and promote hair growth in individuals experiencing pattern hair loss.