9 citations
,
November 2012 in “Hepatology Research” This case study reports the first instance of irreversible alopecia universalis occurring during pegylated interferon-ribavirin therapy in a man with hepatitis C infection, without evidence of immunological or thyroid disorders.
6 citations
,
September 1957 in “Poultry Science” This study found that adding molybdenum to poultry diets depressed growth without affecting feather pigmentation, and copper supplementation tended to counteract the growth inhibition.
4 citations
,
January 2009 in “PubMed” In this study, researchers identified an autosomal dominant mutation (E402K) in exon 7 of the KRT86 gene as a cause of Monilethrix in a large family from Turkey.
3 citations
,
September 2023 in “International journal of impotence research” The authors concluded that finasteride and dutasteride might have serious side effects, including persistent sexual dysfunction for some, necessitating further research and vigilant risk-benefit analysis.
February 2026 in “International Journal of Molecular Sciences” This study found that knocking down the gene SFRP1 in human hair follicles ex vivo prolonged the hair growth phase and increased keratinocyte proliferation, suggesting potential as a therapeutic target for maintaining hair growth in male pattern baldness, while DKK1 knockdown showed no effect.
January 2025 in “Plastic Surgery and Reconstructive Medicine” In this study, plasmatherapy was found to improve immune status indicators in patients with vitiligo, particularly benefiting those with segmental vitiligo by normalizing immune markers and reducing IL-6 levels, suggesting its potential as an adjunct treatment to slow depigmentation progression.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers developed a detailed spatial atlas of healthy human skin and basal cell carcinoma, revealing that basal cell carcinoma likely originates from hair follicles and involves expansion of specific fibroblast subpopulations found in healthy skin.
November 2022 in “Journal of Investigative Dermatology” This study observed that three-dimensional cultures of dermal papilla cells enhanced endothelial cell migration and angiogenesis in vitro, which may improve vascularization in tissue-engineered skin constructs.
July 2022 in “Research, Society and Development” This study observed variable therapeutic responses in dogs with Alopecia X, with some showing complete hair regrowth while others did not, following similar treatments including orchiectomy and supplementation.
December 2020 in “Benha Journal of Applied Sciences” This study found that patients with acne vulgaris had significantly higher serum levels of betatrophin compared to healthy controls, suggesting it may be an independent predictor of acne severity and vulnerability.
January 2014 in “Genes and Cells” This study found that transplanting human cord blood mononuclear cells transfected with a plasmid encoding VEGF and FGF2 into rat skin wounds may accelerate the wound healing process.
January 2006 in “Bohn Stafleu van Loghum eBooks” This article discusses the prevalence and patterns of androgenic alopecia in men and women, highlighting its progression and differences in hair loss distribution between the sexes, but reports no new data.
June 2021 in “The American Journal of the Medical Sciences” This study found that patients with androgenetic alopecia had higher serum homocysteine levels, linked to the mutant MTHFR genotype, and an increased risk of coronary heart disease.
106 citations
,
March 2013 in “Nature Communications” This study found several microRNA-related genetic variants linked to epithelial ovarian cancer risk, with a notable association at the 17q21.31 region, suggesting potential new susceptibility genes.
86 citations
,
June 2018 in “Cochrane library” This review update suggests that mycophenolate mofetil may increase complete disease remission in proliferative lupus nephritis compared to intravenous cyclophosphamide, but with low certainty of evidence.
44 citations
,
June 2023 in “Cell Reports” This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.
25 citations
,
June 2022 in “Developmental cell” In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce follicle multiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hair follicles.
10 citations
,
September 2024 in “Life” This review found that, among 103 patients treated off-label with abrocitinib for conditions beyond atopic dermatitis, favorable clinical outcomes were reported for most cases, except one isolated case involving erythematotelangiectatic rosacea.
8 citations
,
October 2024 in “Cochrane Database of Systematic Reviews” This review found that Tolvaptan is the only drug shown to slow the progression of autosomal dominant polycystic kidney disease, but it does not affect mortality or kidney failure outcomes.
8 citations
,
March 2018 in “Expert Review of Respiratory Medicine” This article reviews the potential of inhalation therapy to restore pulmonary elastin fibers in COPD patients and highlights the need for studies to test its feasibility; it reports no new research findings.
5 citations
,
July 2005 in “British journal of dermatology/British journal of dermatology, Supplement” This case study reports an unusual occurrence of hair growth on the glans penis of a healthy 24-year-old man, which required surgical excision but recurred at a different site.
3 citations
,
August 2024 In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.
3 citations
,
March 2011 in “Informa Healthcare eBooks” Acne in children varies by age and severity, requires a pediatric treatment approach, and may need diagnostic evaluation for underlying conditions.
June 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that finasteride's solubility and bioavailability were improved when using a dimethyl-β-cyclodextrin inclusion complex compared to the drug alone.
May 2013 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that a multimodal microemulsion containing minoxidil, diclofenac, and tea tree oil was significantly more effective and stable than minoxidil alone in treating androgenic alopecia over a 32-week period.
This review discusses various acquired disorders of hair growth in women, such as effluvium and alopecia, but reports no new clinical findings.
January 2003 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the dermatological impacts of hypogonadism in men, including skin thinning, reduced body hair, and skin reactions to testosterone therapy, but reports no new clinical results.
1707 citations
,
December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
710 citations
,
May 2023 in “European Urology” This study highlights that improved diagnostic techniques for prostate cancer could decrease the number of men needing diagnosis and treatment to save one life and identifies avoidable risk factors, such as smoking, diet, and occupation, that may influence prostate cancer risk.
408 citations
,
January 2017 in “Science” This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.