Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that deleting Snai2 and Snai3 genes in mice disrupts immune cell development, resulting in severe autoimmunity and early death due to the loss of immune tolerance.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

This study found that in chimaeric mice models, the pigment distribution and pattern were influenced by the sash genotype, demonstrating the melanocyte-autonomous nature of the beige and leaden loci.

This chapter reviews hyperadrenocorticism in ferrets, covering its causes, symptoms, diagnosis, and treatment options, but reports no new research findings.

The drug TGU was ineffective against small cell lung cancer and caused significant bone marrow suppression.

This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms.

This study suggests that β-catenin plays an important role in wool follicle development in transgenic sheep by enhancing the expression of keratin protein genes.

This review describes the evolution of treatments for relapsing multiple sclerosis, highlighting that while newer potent monoclonal agents can potentially achieve disease remission, they also pose moderate to severe adverse event risks that healthcare providers must understand.

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

This study found that the extent of reducing agents' effects on hair fibers was linked to the electrode potential of the reagents used.

In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

This study found that chronic administration of finasteride affected the isotopic composition of testosterone and nandrolone metabolites, impacting the drug-testing outcomes in athletic contexts.

In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.

This study reported that metallic-glass-coated tattoo needles reduced trauma and improved tattoo quality in pig skin experiments compared to uncoated needles.

This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.

This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.

This study found that finasteride may improve pulmonary and hepatic immune responses in mice when administered after major trauma and hemorrhage.

This guideline summary, endorsed by six Spanish pediatric societies, outlines consensus recommendations for managing childhood asthma, emphasizing diagnosis, maintenance treatment with low-dose inhaled corticosteroids, and patient education for effective control.

In this study, researchers used a mouse model to identify an adipocyte-to-fibroblast conversion pathway that promotes mast-cell recruitment and dermal fibrosis in atopic dermatitis, suggesting a potential therapeutic approach to block this process and reduce inflammation and fibrosis.

This study found that preconditioning human hair follicle-derived stem cells with valproic acid enhanced their survival and migration in ischemic-like conditions by activating autophagy and inhibiting the AKT/mTOR pathway, suggesting this approach could improve stem cell therapies for ischemic stroke.

This study utilized a mouse model of traumatic brain injury to reveal that acute neurotrauma triggers widespread lipid metabolism reprogramming and storage lipid accumulation in microglial and monocyte populations, leading to lysosomal dysfunction, inhibited autophagy, and exacerbated inflammation through a pathological feedback loop.

This review discusses the role of steroid 5 alpha reductase 2 in converting testosterone to DHT and its association with conditions like benign prostatic hyperplasia and prostate cancer; it reports no new results.

This review highlights the medicinal potential and pharmacological activities of the plant Plumbago zeylanica, while emphasizing the critical need for mass propagation methods to address its over-exploitation and support the development of novel herbal medicines.

In this study, primary cilia were found to contribute to meibomian gland enlargement and lipid production, though they are not necessary for normal gland development.

Different medications can cause serious side effects in some people.

This study found that glucose starvation and hypoxia are physiological triggers of ER stress in in vitro differentiated adipocytes, rather than high concentrations of saturated fatty acids, cholesterol, or proinflammatory cytokines.

This study found that obesity in women may impair endometrial stromal function and contribute to reproductive complications, possibly due to metabolic influences rather than immune cell differences.

This study observed that facial feminization surgery significantly improved facial appearance and alleviated gender dysphoria among Chinese transgender females, with all patients expressing satisfaction post-surgery.

This article reviews the biological causes and treatment options for facial aging but reports no new clinical findings.