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This review discusses advancements in skin microphysiological systems, such as 3D bioprinting, skin organoids, and skin-on-a-chip, and their effectiveness in emulating human skin functions for research and preclinical applications, highlighting the potential for replacing animal testing with these innovative technologies.

This study highlights the clinical potential of microneedles as an innovative transdermal drug delivery system for treating various skin diseases with minimal pain and high patient compliance.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

This study investigated the extracellular polysaccharides from the edible green alga Parachlorella sp. BX1.5, finding that they have potential applications in cosmetics and health products due to their stability, antioxidant properties, and effects on hair growth in mice.

This study reported that fermented grapeseed oil may enhance hair permeability and improve strength and color retention in chemically treated hair compared to regular grapeseed or silicone oils.

In diabetic mice, this study reported that the multifunctional hydrogel CPGel achieved complete wound closure in 21 days, showing promise in improving chronic wound healing through antibacterial, antioxidative, and tissue regeneration properties.

In this study, bioengineered hair germ microspheres made from HME hydrogels promoted hair follicle regeneration in vivo, suggesting a promising approach for hair loss treatment.

This study found that Platycladus orientalis flavonoids may reduce oxidative damage and slow melanin degradation in AGA-affected hair, improving its quality.

This review highlights the use of microneedling devices and patches to deliver cosmetic agents through the skin, noting their applications in skin rejuvenation and safety considerations such as potential skin irritation and infection.

This study found that an injectable calcium alginate-amelogenin hydrogel is biocompatible, degradable, anti-inflammatory, and promotes osteogenesis, which may enhance the bone healing process in jaw and facial bone defect areas by mediating the bone immune microenvironment.

This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.

This study highlights the diverse applications of *Perilla frutescens* in traditional medicine, cuisine, and industrial settings, noting its significant antioxidant and antimicrobial properties in experimental models, as well as research efforts to enhance its bioactive content and ensure safety and standardization.

This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.

In this study, researchers identified ten key genes involved in the periodic development of hair follicles in cashmere goats, highlighting the importance of the Wnt signaling pathway and cell cycle in this process.

This review explores the potential health benefits of food bioactive compounds, specifically polyphenols, as preventive agents against non-communicable diseases like cancer and cardiovascular disorders, while also addressing challenges like bioavailability and industrial applications.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This review discusses the potential of nanoparticles to modify angiogenesis processes for therapeutic applications and reports no new clinical results, highlighting challenges and future prospects in treating angiogenesis-related diseases.

This review introduces a framework to integrate bioinspired conductive materials and advanced 3D/4D printing in regenerative medicine for dynamic, responsive tissue regeneration, emphasizing the potential of smart scaffolds to adapt to physiological cues.

This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.

In this study, researchers investigated EGCG's spectroscopic properties and its interaction with DPPG lipid, finding that both experimental and theoretical approaches agree on the electronic transitions and reveal an increased absorbance due to molecular interactions.

This review explores the applications of phytonutrient-based biosensors in micro-electrochemical systems and reports no new experimental findings, emphasizing the potential and challenges of this innovative approach.

This review discusses advanced biomedical technologies, such as nanotechnology and stem cell-based approaches, for treating androgenetic alopecia, detailing their benefits, current applications, and challenges, without reporting new experimental results.

This review assesses the potential of smart dressings, engineered to respond to various stimuli, as advanced treatments for chronic inflammatory skin diseases by examining their activation mechanisms and proposing future developments like integrating AI and closed-loop monitoring for adaptive therapy.

This study found that a natural illite-based carrier could deliver minoxidil topically with preserved efficacy, minimizing solvent toxicity, and showed hair-growth-promoting activity via anti-inflammatory and pro-proliferative mechanisms in mice.

This review summarizes recent advances in alopecia management, focusing on combining synthetic and herbal therapies with innovative drug delivery systems like nanocarriers to enhance effectiveness and reduce side effects, while noting challenges with skin penetration and bioavailability.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This study developed a microneedle system using black phosphorus nanosheets and baicalin for treating androgenetic alopecia, finding it effectively enhanced drug penetration and follicular targeting while showing synergistic efficacy and safety in preclinical tests, including in vivo model efficacy against testosterone-induced hair loss.

This study developed caffeine-loaded nanoparticles coated with ultradeformable liposomes for better hair follicle delivery, showing non-cytotoxicity and potential to reduce oxidative stress in DHT-damaged cells, suggesting an alternative treatment for androgenetic alopecia.

This study reports that Hair RiseTM microemulsion, made from plant extracts, significantly enhanced hair follicle cell growth and improved hair growth signaling pathways, suggesting it as a plant-based alternative for androgenetic alopecia treatment.

Hemp seed biomaterials may reduce hair loss and improve hair growth.