Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that a novel dietary supplement, AGA-P, when combined with minoxidil and finasteride, significantly improved the clinical efficacy of these drugs for treating mild-to-severe androgenic alopecia compared to drug treatment alone over six months.

In this study, injectable microdepots containing rapamycin and poly(lactic-co-glycolic acid) were developed and demonstrated to effectively promote hair regrowth in mice by sustaining drug release and inducing anagen phase transition in hair follicles through modulating autophagy and the Wnt/β-catenin pathway.

This study used human stem cell-derived skin organoids to model EV-A71 infection, revealing that various skin cell types are susceptible to the virus and identifying a potential drug target and replication inhibitor, suggesting its utility for studying skin infectious diseases and drug screening.

This study developed a microneedle system using black phosphorus nanosheets and baicalin for treating androgenetic alopecia, finding it effectively enhanced drug penetration and follicular targeting while showing synergistic efficacy and safety in preclinical tests, including in vivo model efficacy against testosterone-induced hair loss.

This study found that in male Wistar rats, finasteride administration reduced neural cellular activity markers and 5-alpha reductase type 2 expression in brain tissue, with some recovery occurring after drug withdrawal, unlike persistent 5-alpha reductase type 2 suppression.

This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.

This review examines the potential of K18 as a diagnostic and prognostic marker in epithelial-derived tumors, highlighting its specific expression in tumor tissues and interaction with proteins involved in tumor progression, without reporting new clinical findings.

This study explored the use of spanlastic vesicles to enhance the delivery of bimatoprost for treating alopecia and found that a bimatoprost-loaded nanogel significantly increased skin drug accumulation and improved hair regrowth in a mouse model, outperforming both naive bimatoprost gel and commercial minoxidil formulations.

In this study, the researchers developed and optimized a bilayer tablet containing Tamsulosin and Finasteride, achieving sustained and immediate drug release with favorable release kinetics, including first-order and anomalous diffusion mechanisms, through in vitro testing.

In this mouse study, researchers found that nanoparticles loaded with umbilical cord-derived stem cell membranes and minoxidil enhanced hair growth by improving drug solubility and transdermal delivery, increasing VEGF, IGF-1, MKI67, and CTNNB protein levels in skin tissue compared to regular minoxidil.

In this study, nanoparticles developed with Minoxidil-loaded thiolated β-CDs showed promise for topical scalp use, as they significantly improved drug retention on hair and displayed no irritation in rabbits.

This narrative review examines the technological advancements and clinical applications of liquid injectable platelet-rich fibrin (i-PRF), discussing its use across regenerative periodontology, sports medicine, and more, as well as its potential as a drug delivery system.

In this study, the authors developed a medicated face mask using electrospun fibers to deliver the active compound Eflornithine hydrochloride for managing hirsutism. The mask showed promising drug release characteristics, a high safety profile, and reduced hair growth in mice.

This study created a Wnt3a protein gradient using Multiphoton Microfabrication technology, which improved hair-inductive properties in mouse and human hair dermal papilla cells, suggesting potential applications in hair regeneration research and drug screening.

This review paper discusses the effectiveness of repurposed drugs and potential novel therapies for treating COVID-19, highlighting remdesivir as the only FDA-approved medication and listing others with Emergency Use Authorization.

This study found that proretinal nanoparticles, applied topically, are safe and effective for penetration into hair follicles, enhancing retinoid biological activity in the skin while reducing irritation compared to conventional retinal formulations.

In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.

This study found that using gallate-containing formulations like EGCG or tannic acid increased the solubility and controlled release of finasteride in microspheres, enhancing its dermal penetration in pig skin by 10 to 50 times compared to a control.

This study suggests that combining drugs with hair grafts may effectively regress male androgenetic alopecia from Hamilton type V to type III when evaluated using the Dynamic Multifactorial Classification.

This study found that fluconazole increased water transport in renal cells via effects on aquaporin-2 channels, suggesting potential as a treatment for nephrogenic diabetes insipidus, though clinical trials are needed to confirm efficacy in humans.

In this study, finasteride 1 mg/day for 12 months did not improve hair growth or slow hair thinning in postmenopausal women with androgenetic alopecia compared to placebo.

In this study, 19 patients treated with finasteride for androgenetic alopecia developed moderate to severe depression, which resolved after stopping the medication, suggesting an association between finasteride and mood disturbances.

This article reviews the pharmacology of bimatoprost and prostamide F2α, highlighting bimatoprost's therapeutic applications in glaucoma, hair growth, and potential fat reduction, without reporting new experimental results.

Apremilast was not effective in treating moderate-to-severe alopecia areata.

This pharmacovigilance study found an increased association of suicidality and psychological adverse events with finasteride use, especially among younger patients using it for alopecia.

This study discusses levetiracetam's role as an alternative treatment for idiopathic generalized epilepsies, highlighting its potential effectiveness, especially for patients unsuitable for valproate.

This review discusses the potential of organoids in modeling COVID-19 disease and developing therapies, without reporting new results, and highlights opportunities and challenges in their application for research.

This review discusses AR-modulating agents developed between 2012 and 2018, highlighting challenges with ligand-binding domain antagonists and proposing nonconventional approaches targeting other domains as promising strategies.

Oral minoxidil effectively controls blood pressure quickly and safely.

This study reported that while general patient characteristics and adverse event incidence for eribulin were comparable between a healthcare claims database and post-marketing surveillance, significant differences in some side effects such as neutropenia were observed.