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The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Finasteride doesn't effectively treat hair loss in postmenopausal women.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

PGD2 stops hair growth and is higher in bald men with AGA.

Lactate production is important for activating hair growth stem cells.