57 citations
,
November 1987 in “Pediatric Dermatology” This article reviews common hair growth abnormalities in children, emphasizing the importance of distinguishing normal development from potential signs of metabolic disorders and indicates no new clinical results.
40 citations
,
June 2013 in “Biomaterials” This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.
35 citations
,
July 2018 in “Cell Reports” This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.
21 citations
,
October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
18 citations
,
August 2012 in “Journal of The American Academy of Dermatology” This report describes a case where a sex reassignment patient on estrogen therapy experienced complete hair regrowth on a previously fully alopecic scalp.
9 citations
,
June 2008 in “Springer eBooks” Understanding hair follicle structure is key for treating hair disorders and could help develop new treatments.
5 citations
,
January 2014 in “Journal of Cutaneous and Aesthetic Surgery” A woman had 13 non-cancerous cysts on her scalp successfully removed in one surgery.
1 citations
,
February 1993 in “Nursing Standard” This article highlights that nurses may not be sufficiently aware of the potential for various drug groups, beyond cytotoxic drugs, to cause alopecia, and emphasizes the importance of early recognition of this side effect.
January 2018 in “Georg Thieme Verlag eBooks” Hair transplantation is a surgical procedure to move hair to bald areas, requires good donor hair, and results show in about a year.
243 citations
,
October 2003 in “Developmental biology” This study identified ectodin as a novel BMP inhibitor that modulates BMP signaling in ectodermal development by interacting with SHH and FGF pathways.
236 citations
,
July 2001 in “Trends in Molecular Medicine” This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.
157 citations
,
April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
118 citations
,
May 2015 in “European journal of pharmaceutics and biopharmaceutics” This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.
117 citations
,
November 2006 in “Experimental Dermatology” This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.
115 citations
,
March 2019 in “Nature Communications” This study identified significant genetic associations with frontal fibrosing alopecia at four genomic loci, suggesting it is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07: 02 allele.
76 citations
,
June 2008 in “Journal of the American Academy of Dermatology” In this study, key histologic features such as mucinous perifollicular fibroplasia were identified to aid in the diagnosis of lichen planopilaris.
67 citations
,
July 1985 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that males have significantly longer hair on their thighs compared to females, mainly due to a longer anagen phase and a greater rate of growth.
59 citations
,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
48 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.
47 citations
,
June 1996 in “International Journal of Legal Medicine” This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.
46 citations
,
October 2009 in “Archives of Dermatology” This study found that loose anagen hair syndrome is a common form of alopecia in young girls, typically presenting with thin, sparse hair and usually confirmed by a hair-pull test.
46 citations
,
May 1986 in “Seminars in Reproductive Medicine” Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
40 citations
,
July 2017 in “Frontiers in Medicine” This review highlights that in children, hair loss can be attributed to diverse conditions like alopecia areata and tinea capitis, and stresses the importance of a holistic approach to diagnosis and management, including psychosocial support due to limited effective treatments.
40 citations
,
June 2013 in “Scientific Reports” This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.
34 citations
,
August 1966 in “Experimental cell research” This study examined developing hair cortex with electron microscopy and found that keratin fibrils form between specific regions in hair follicles and aggregate into twisted cables.
29 citations
,
December 1998 in “Seminars in Cutaneous Medicine and Surgery” This review examines recent approvals and emerging treatments for androgenetic alopecia, discussing newly approved drugs like Propecia and Rogaine Extra Strength 5%, but without presenting new clinical results.
28 citations
,
September 1998 in “Medical Clinics of North America” This article reviews common causes of hair loss, noting that a well-directed history and examination are often sufficient for diagnosis, and reports no new clinical findings.
24 citations
,
January 2003 in “Journal of Investigative Dermatology” In this study, a synthetic antagonist of the p75 neurotrophin receptor was found to significantly inhibit hair follicle regression in murine skin cultures, suggesting a potential role in treating hair disorders characterized by premature catagen entry.
24 citations
,
May 2016 in “Stem Cell Reviews and Reports” This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.
24 citations
,
July 2015 in “Biogeosciences” This study found that the growth of hair ice on dead wood requires the biological activity of a winter-active fungus, specifically Exidiopsis effusa, which shapes and stabilizes the ice structures.