research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome
Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
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120-150 / 491 resultsresearch The Phenotypic and Genotypic Spectra of Ichthyosis With Confetti Plus Novel Genetic Variation in the 3′ End of KRT10
Ichthyosis with confetti is a genetic skin disorder with consistent ectodermal malformations and various KRT10 gene mutations.
research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse
Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.
research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice
Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
research Index
The document is a detailed medical reference on skin and genetic disorders.
research Formation of the Cornified Envelope
The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration
The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
research The Editor's Choice: Summary of Studies on Skin and Hair Conditions
UV radiation may cause DNA changes in skin, certain UVB therapy helps psoriasis, a new gene mutation is linked to mild piebaldism, different immune cells affect psoriasis, a drug promotes hair growth, and some cancer drugs could treat skin barrier issues.
research Disorders of Keratinization
Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.
research A Novel Animal Model of Desmoglein 1 (Dsg1) Deficiency Reveals an Essential Role for Dsg1 in Epidermal Barrier Formation
Dsg1 is essential for maintaining a healthy skin barrier in mice.
research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis
Trichohyalin is also found in the outer layers of normal human skin.
research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells
The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.
research Cutaneous Responses to Systemic Iron: A Potential Role for Epidermal Turnover in Mammalian Iron Excretion
Skin may help in getting rid of excess iron through the process of skin cell renewal.
research Three-Dimensional Imaging of Tight Junction Network Across Multiple Layers of Human Epidermis by Array Tomography Using Backscattered Electron-Mode Scanning Electron Microscopy
The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.
research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
Wnt ligands are crucial for hair growth and repair.
research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway
Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.
research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling
The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research Skin Keratins
Keratins are important for skin cell health and their problems can cause diseases.
research Keratin and Skin Disorders
Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.
research Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis
Minoxidil foam 5% effectively treats hair loss in both frontal and vertex scalp regions.
research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function
Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
research Perspectives on Hair Evolution Based on Comparative Studies on Vertebrate Cornification
Hair in mammals likely evolved from glandular structures, not scales.
research The Epithelial Stem Cell Niche in Skin
Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
research Skin Barrier, Phenotypic and Genotypic Characterization of Autosomal Recessive Ichthyosis in TGM1-Deficient Jack Russell Terriers and Response to Topical Ceramide
Topical ceramide treatment partially improves the skin condition in Jack Russell Terriers with a genetic skin disorder.
research The Role of the Skin Microbiome in Wound Healing
The skin microbiome helps heal wounds and can be targeted to improve healing.
research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin
Not having enough cystatin M/E protein causes less hair growth and dry skin.
research Hair, Cutaneous Homeostasis, and Stem Cell Functions
Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
research The Potential Application of Ecklonia Cava Extract in Scalp Protection
Ecklonia cava extract may protect the scalp from pollution and improve its health.