30 citations
,
April 2017 in “Journal of structural biology” This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
30 citations
,
December 2017 in “Medical Hypotheses” This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.
29 citations
,
July 2008 in “Journal of Cutaneous Pathology” This study found that follicular streamers are mostly present in non-scarring alopecia cases, and tracking their location can improve diagnosis accuracy.
29 citations
,
March 2001 in “Clinics in Dermatology” This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.
29 citations
,
December 2012 in “Fibrogenesis & Tissue Repair” This review discusses the roles of tissue-specific and mesenchymal stromal cells in tissue repair and reparative disorders, highlighting potential therapeutic targets for muscle, heart, and lung tissues.
28 citations
,
December 2011 in “Biocatalysis and biotransformation” This study found that a peptide treatment using Protein disulphide isomerase improved the mechanical and thermal properties of over-bleached hair by promoting deeper peptide penetration and attachment.
28 citations
,
March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
28 citations
,
May 1998 in “Skin Research and Technology” This study characterized the stress-strain properties of the human scalp and found that its stiffness increases significantly with load, providing valuable insights for planning scalp surgery procedures.
24 citations
,
November 2015 in “Scientific reports” This study discovered a new region in the hair cortex where intermediate filaments are both aligned with the hair's axis and orientationally ordered, influenced by the cuticle boundary.
23 citations
,
January 2015 in “Stem cells international” This study found that keratin coatings from human hair may improve the colony-forming efficiency of human mesenchymal stem cells by moderating donor variability, suggesting a potential use in clinical applications.
23 citations
,
January 2002 in “Journal of Cutaneous Medicine and Surgery” This study suggests that finasteride may affect hair follicle growth by altering the expression of caspases and XIAP, potentially regulating the anagen phase of hair growth.
22 citations
,
November 2018 in “Brazilian Journal of Pharmaceutical Sciences” This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.
22 citations
,
April 2011 in “Anais Brasileiros de Dermatologia” This report describes two cases where lichen planopilaris may have compromised the hair follicles in both donor and recipient areas following follicular unit transplantation.
21 citations
,
December 2011 in “Chungara” This study shows that environmental contamination affects mummy hair, suggesting that using it to assess ancient people's health or nutrition should be approached cautiously.
21 citations
,
September 2008 in “Magnetic Resonance Imaging” This study utilized magnetic resonance imaging to noninvasively visualize and differentiate skin structures in rat skin, finding a significant correlation between MRI data and histological areas.
21 citations
,
January 2002 in “Journal of Cutaneous Medicine and Surgery” This study reports that finasteride treatment in men with androgenetic alopecia appears to restore caspase and XIAP expression in hair follicles to levels similar to those in individuals without the condition.
21 citations
,
September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology” This study found that minoxidil inhibited lens epithelial cell migration, proliferation, and collagen secretion in vitro, suggesting it may help prevent postoperative capsular opacification.
19 citations
,
January 2009 in “International review of cell and molecular biology” This review explains the mechanical composition and molecular interactions that determine hair's mechanical properties, without providing any new experimental findings.
17 citations
,
July 2019 in “Scientific reports” This study investigated lipid loss in hair caused by surfactants and found that surface and internal modifications can significantly protect different lipids from depletion, with internal modification preventing 52.0 to 81.3% of lipids in certain groups.
17 citations
,
June 2018 in “Frontiers in Physiology” This study found that acellular dermal matrix scaffolds may facilitate full-thickness skin wound healing by promoting a pro-regenerative immune response through M2 macrophage polarization via the Lamtor1 pathway.
17 citations
,
May 2013 in “Oral and Maxillofacial Surgery Clinics of North America” This article reviews the complex challenges of managing scalp and cranial deformities post-trauma or surgery, advocating for better multidisciplinary approaches to enhance outcomes, but reports no new results.
16 citations
,
August 2019 in “Cell Proliferation” This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.
16 citations
,
December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
16 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review explores new theories, diagnostic tools, and management strategies for primary cicatricial alopecia but reports no new clinical findings.
14 citations
,
February 2021 in “International Journal of Pharmaceutics” In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.
14 citations
,
January 2006 in “Australasian journal of dermatology” This case report describes an atypical presentation of alopecia areata in a 53-year-old postmenopausal woman, which may resemble frontal fibrosing alopecia and complicate diagnosis.
14 citations
,
May 1987 in “Archives of Dermatology” This article discusses tissue-expansion augmented scalp reduction as a surgical option for cicatricial alopecia patients who are otherwise not candidates for traditional hair replacement techniques, but it reports no new clinical results.
13 citations
,
October 2020 in “Journal of Neural Transmission” In this study, CD34-positive progenitor cells in irradiated salivary glands were observed to potentially aid in blood vessel formation and remodeling, suggesting their role in tissue healing after radiotherapy.
13 citations
,
May 2016 in “International journal of biological macromolecules” This study demonstrated that molecular dynamics simulations of keratin could effectively model the mechanical properties of hair, aligning well with experimental data, especially when conducted in vacuum conditions.
13 citations
,
April 2001 in “International Journal of Dermatology” Different types of scarring alopecia may be stages of one disease, and accurate diagnosis is crucial to prevent permanent hair loss.