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This study found that culturing fibroblasts on stiffer substrates mimicking fibrotic wounds led to an aligned EDA fibronectin matrix with thinner fibers and decreased YAP activity, suggesting disrupted signaling that might be restored to promote regenerative wound repair.

This study found that electrospun membranes with aligned surface topography enhanced wound healing and hair follicle regeneration while modulating the immune response in a mouse skin wound model.

This study tested a microneedle patch on rabbit and pig models to support skin regeneration, revealing that the treatment accelerated wound closure, reduced scar formation, and promoted hair-bearing tissue and follicle growth, suggesting a trauma-guided framework for skin restoration.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

In this study, hair follicle transplantation into nonhealing ulcers promoted rapid wound closure, with differing scar quality and hair growth between the central and peripheral wound areas.

This study found that topical application of TGF-β mimic promoted enhanced wound healing and tissue regeneration in mice, suggesting its potential as a therapeutic option for improving wound healing.

This research observed that diabetes impairs wound healing in mice by disrupting key mechanotransduction pathways in fibroblasts, which are crucial for the healing process. The study also suggests transcriptomic changes could inform future diabetic wound repair therapies.

This study found that a specific Gli1+ subpopulation in the perivascular niche plays a crucial role in wound healing by differentiating into myofibroblasts, with their genetic ablation impairing wound repair.

This source highlights the challenge in achieving scarless healing with skin appendage regeneration for wounds and notes that vitamin A derivatives show promise for promoting new follicle growth. However, specific results from this research are not reported in the abstract.

In laboratory research, investigators found that apoptotic vesicles from interleukin-10-treated fibroblasts promote wound healing and reduce fibrotic scarring by enhancing mitochondrial function, modulating collagen composition, and inhibiting the Hedgehog signalling pathway, offering potential for regenerative medicine applications.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.

This study found that implanting HAP stem cells in a mouse model accelerated wound closure and reduced scar formation, suggesting potential for scar-free wound healing.

This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.

This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.

In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.

This study found that α-13′-carboxychromanol significantly accelerated wound healing and improved tissue quality in a mouse model, especially when delivered with bacterial nanocellulose under diabetic conditions.

This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.

This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.

This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.

This paper contains no findings, serving instead as contact information for a dermatologist with no financial conflicts of interest disclosed.

This study found that using hair follicle units to treat hard-to-heal wounds led to complete or partial closure in most patients, with reduced operation time, minimal morbidity, and low complication rates and costs.

This study found that combining mesenchymal stromal cells from adipose tissue and hair follicles with soy protein and β-chitin scaffolds significantly reduced wound healing time and improved skin regeneration in vivo.

This study identified CD201+ fibroblast progenitors in mouse skin that regulate wound healing through differentiation into specialized cell types, with retinoic acid and hypoxia influencing this process.

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

This article proposes two new categories of cicatricial alopecia—“unstable” and “stable”—and suggests surgical excision as preferred over hair transplantation, especially for unstable cases.

This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.

This study observed that post-surgical use of chlorhexidine digluconate mouth rinse in patients may induce a fibrotic transformation in gingival tissue, promoting a scar-like wound healing response.

In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.