Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the heterogeneity of Tregs in normal and tumor environments, emphasizing the complexity of targeting tumor-resident Tregs while maintaining systemic immune tolerance, but reports no new findings.

This research explores if COVID-19, analogous to SARS-CoV, may result in long-term pulmonary fibrosis in recovered patients, although current evidence on the persistence or resolution of lung changes over time remains unknown.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

In this study, researchers discovered that fat grafting helps reduce dermal fibrosis in radiation-injured mouse skin by decreasing specific fibroblast subpopulations associated with Fra/c-Jun signaling.

MicroRNA-21 could help diagnose and treat skin fibrosis.

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

This research concludes that adipose mesenchymal stem cells are uniquely evolved to manage skin inflammation in newborns and their released molecules are the safest and most effective for skin therapeutics.

In this study using a mouse model, researchers utilized single-cell RNA sequencing to create a comprehensive cellular atlas of infected versus uninfected wounds, revealing that Enterococcus faecalis infections lead to immunosuppressive changes in skin cells and disrupt normal wound healing processes.

This review highlights the complications of radiation therapy, specifically radiation cystitis, and explores the potential of mesenchymal stem cell-based therapies for tissue repair while discussing their therapeutic potential and limitations.

This study found that treating wounds in mice with the drug verteporfin, which inhibits mechanical signaling, leads to skin regeneration associated with the activation of Wnt pathway proteins.

This study found that CXCL12+ fibroblast subsets in mouse skin play a critical role in recruiting neutrophils and defending against S. aureus infection, with similar fibroblast activity observed in human psoriatic skin.

This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.

This review discusses the role of mTOR kinase in pulmonary fibrosis and explores how mTOR inhibitors may help slow the progression of this condition, but it reports no new results.

This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.

This study found that fibroin/gelatin and spidroin microparticles increased re-epithelialization rates and inhibited scar formation in mouse models of deep skin wounds.

This study found that activating liver X receptors with an agonist reduced skin fibrosis in experimental models, particularly in inflammation-driven conditions, by inhibiting macrophage infiltration and interleukin-6 release.

In this study, SIRT1-modified human umbilical cord mesenchymal stem cells reduced peritoneal fibrosis in a rodent model, suggesting potential as a treatment strategy for peritoneal dialysis-induced damage.

This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.

This review discusses the evolution of adipose tissue research in regenerative medicine, from tissue transfer to cell-free bioengineering applications, highlighting its therapeutic potential, current limitations, and future directions.

In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.

This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.

In this study, researchers observed that African spiny mice, Acomys cahirinus, are capable of regenerating skeletal muscle in dermal wound sites, unlike common mice, Mus musculus.

This review highlights the emerging role of long non-coding RNAs (lncRNAs) in dermatology, suggesting that lncRNAs significantly impact signaling pathways involved in normal skin functions and skin diseases, offering potential as biomarkers and therapeutic targets.

This review discusses the effects of minoxidil on human skin fibroblasts, reporting its potential to inhibit lysyl hydroxylase activity and DNA synthesis, suggesting it may have antifibrotic applications for collagen-related skin conditions.

In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.

This study found that cold atmospheric plasma can accelerate wound healing processes and reduce bacterial growth, including drug-resistant strains, suggesting its potential as a novel treatment for chronic wounds.

This proof-of-concept study reported that a new, ultra-fast, one-step immunohistochemistry method improved the interpretation of Mohs surgery slides, particularly for poorly differentiated tumors.