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Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Aging causes skin stem cells to work less effectively.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Fat cells in the skin help start healing and form important repair cells after injury.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Lowering testosterone speeds up wound healing in male mice.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Oxidative stress affects hair loss in men with androgenetic alopecia.

Skin fat helps with body temperature control and has other active roles in health.