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In this study, researchers observed that melatonin-mediated LncRNA MTC in Liaoning cashmere goat skin fibroblasts enhances cell proliferation by interacting with the GSTM1 protein, affecting its complex formation with ASK1 and thereby inhibiting apoptosis, which may be relevant for improving cashmere growth.

This study does not report results but provides integrated single-cell RNA sequencing data from multiple mouse wound healing models, offering resources for studying fibroblast-driven changes in the extracellular matrix and signaling during the healing process.

This study found that TNC + fibroblasts are crucial in neuro-immune interactions in various skin diseases, particularly inflammation and tumors, by engaging extensively with immune cells and overexpressing inflammatory genes, suggesting their significant role in skin abnormalities.

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

This study found that different stressors causing premature senescence in fibroblasts resulted in distinct changes in lipid profiles, particularly sphingolipids, which may affect the behavior of senescent skin cells.

This study found that the transcription factor Lef1 is crucial for normal skin and hair development and wound healing, highlighting its role in regulating essential genes and pathways in papillary fibroblasts.

The researchers in this study found that neonatal mouse skin fibroblasts show distinct chromatin landscapes directing differentiation into dermal papilla or adipocyte lineages, and such plasticity may inform strategies for enhancing regenerative capacities in adult skin.

This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.

This study found that fibroblasts from mature skin showed significantly reduced mechanical force production compared to young skin fibroblasts, suggesting age-related changes in cellular mechanical properties.

This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.

In this study using a mouse model, researchers found that expressing Lef1 in dermal fibroblasts may enhance skin regeneration without affecting normal development.

This study found that DPP4 is significantly involved in matrix deposition and fibrosis in human skin fibroblasts, although the exact functions of DPP4 remain unclear.

This study found that CYP11A1-derived vitamin D3 analogs inhibit fibroblast proliferation and decrease collagen production through VDR expression, showing potential antifibrotic and antiproliferative activity in human dermal fibroblasts.

In this study, embryonic skin fibroblasts from day E17.5 and postnatal day P5, but not E14.5, effectively supported hair follicle formation, indicating distinct developmental states and differentiation capacities.

This research proposes a comprehensive "four-dimensional technology toolbox" for reprogramming wound-repair cells, aiming to treat chronic non-healing wounds like diabetic foot ulcers by altering fibroblasts, keratinocytes, and macrophages to regenerative phenotypes, and addressing clinical translation challenges.

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

In this study, Almet et al. (2023) compiled integrated single-cell RNA sequencing data from multiple mouse datasets to investigate how fibroblasts evolve during wound healing by examining changes in the extracellular matrix and signaling pathways.

This study found that melatonin-mediated lncRNA018392 accelerated cell proliferation and inhibited apoptosis in cashmere goat skin fibroblasts by upregulating the expression of the nearby gene CSF1R.

In this study, collagen type I, skin fibroblasts, and macrophages did not show remarkable changes in androgenic alopecia patients' scalp tissues after treatment with 1550 nm fractional Er:Glass laser, despite improved hair regrowth.

This study reported that a skin equivalent model using human outer root sheath cells and fibroblasts showed the formation of structures similar to human dermis and epidermis within two weeks after transplantation into mice.

In this study, transient transfection of the HIF-1α gene into fibroblasts led to increased VEGF expression, which may enhance the growth and anagen phase of human hair follicles in vitro.

This study found that iontophoresis with growth factor cocktail including fibroblast growth factor 5-short significantly increased hair density in patients with androgenetic alopecia over 24 weeks.

This study investigated the effects of GFC with FGF5s and NMN at a depth of 0.8 mm using a microneedle for treating hair loss, but the abstract provides no measurable results.

This study found that treating androgenetic alopecia patients with microneedle-delivered GFC containing FGF5s and NMN increased hair density and diameter compared to normal saline.

A treatment called Cellcurin, combined with microneedling, significantly increased hair density and diameter in patients with hair loss.

This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

This study found that measuring 24-OHase induction by 1,25(OH)2D3 in cultured skin fibroblasts is a sensitive test for detecting genetic defects in the 1,25(OH)2D effector pathway.

This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.