research 0140 Delineating key molecular programs that induce hair-follicle-inductive dermal fibroblasts using a novel single-cell genomic approach
Wnt and SHH pathways help form hair follicles by coordinating cell processes.
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330-360 / 1000+ resultsresearch 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa
Scalp hair follicle cells help protect and heal skin in certain skin conditions.
research 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells
Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.
research Direct Conversion of Human Fibroblasts into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule
research 1323 Human dermal fibroblasts and mast cell populations are altered in hidradenitis suppurativa, with epithelial-mesenchymal-transition signals ameliorated by spleen tyrosine kinase antagonism.
This study demonstrates that human epidermal stem cells can adapt to environmental temperature changes through mTOR signaling, and prolonged inhibition of mTORC1 supports stem cell maintenance, which may be vital for regenerative medicine.
research Comparison of two methods for isolation and culture of human foreskin fibroblasts.
The researchers reported that human foreskin fibroblasts isolated by enzyme digestion method proliferated faster and were purified more quickly than those isolated by the inverted tissue culture method; additionally, post-psoralen photoactivation therapy moderately repaired UVB-induced damage in these fibroblasts, suggesting potential clinical applications.
research Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation
This study found that cardiac fibroblasts significantly enhance the maturation of neonatal mouse and human embryonic stem cell-derived cardiomyocytes, suggesting a pivotal role in postnatal heart development and disease.
research CD34 + cell–derived fibroblast-macrophage cross-talk drives limb ischemia recovery through the OSM-ANGPTL signaling axis
This study identified that bone marrow-derived CD34+ cells act as fibroblast progenitors to enhance tissue regeneration in ischemic limbs by promoting angiogenesis through interactions with macrophages.
research Exploring the Overlooked Roles and Mechanisms of Fibroblasts in the Foreign Body Response
This review discusses the roles of fibroblasts in foreign body response and highlights the need for further research on their specific functions to improve antifibrotic and regenerative therapies.
research Comparison of hair dermal cells and skin fibroblasts in a collagen sponge for use in wound repair
research Cosmetic Potency of Puerariae Radix in Dermal Fibroblasts
In this study, the ethanol extract of Puerariae Radix was found to promote proliferation and ERK activation in human dermal fibroblasts, suggesting its potential as a new cosmetic ingredient.
research Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells
research Testosterone stimulates proliferation and inhibits interleukin‐6 production of normal and hereditary gingival fibromatosis fibroblasts
In this study, dihydrotestosterone increased proliferation and decreased IL-6 production in in-vitro fibroblasts from hereditary gingival fibromatosis and normal gingiva, effects partially reversed by anti-androgens.
research Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
This study found that Wnt signaling, crucial for lung development, may be disrupted in severe asthma, potentially affecting cell proliferation and senescence through complex mechanisms.
research Photocrosslinkable Chitosan Quaternary Ammonium Salt-Based Ternary Hydrogel with Fibroblast Growth Factor 21 for Diabetic Wound Healing
In this study, researchers developed a new hydrogel incorporating fibroblast growth factor 21 that improved wound healing in diabetic mice by reducing inflammation and enhancing skin repair, suggesting strong potential for future clinical application in diabetic wound management.
research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair: Wnt1/βcatenin injury response regulates cardiac repair
This study found that a pro-fibrotic Wnt1/βcatenin injury response is crucial for maintaining cardiac function following acute ischaemic cardiac injury by activating the epicardium and cardiac fibroblasts.
research Anabolic potential of bone mineral in human periosteal fibroblasts using steroid markers of healing
In this study, a deproteinized bone mineral showed potential to increase DHT production, suggesting an anabolic effect on human periosteal fibroblasts with possible implications for wound healing.
research 0073 Single-cell analysis reveals divergent dendritic cell-fibroblast signaling in lesional versus non-lesional cutaneous lupus
research Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro
This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.
research 471 Senolytic Potential of Fisetin and ABT Compounds in Dermal Fibroblasts
research 441 Anti-melanoma gene signature in dermal sheath fibroblasts from scalp hair follicles in Recessive Dystrophic Epidermolysis Bullosa (RDEB)
research Faculty Opinions recommendation of Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
research Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells
research Effect of minoxidil-sulfate on cultured human hair papilla cells (PCs) and root sheath fibroblasts(RSFs)
research The effect of minoxidil analogues and metabolites on the contraction of collagen lattices by human skin fibroblasts
research Stable transfection and identification of a hair follicle-specific expression vector of IGFBP-5 in goat fetal fibroblasts
This study constructed a hair follicle-specific expression vector for IGFBP-5 in Inner Mongolia Cashmere goat cells, allowing for future functional genetic analyses and potential use in nuclear transfer.
research Blue Laser Irradiation Decreases the ATP Level in Mouse Skin and Increases the Production of Superoxide Anion and Hypochlorous Acid in Mouse Fibroblasts
This study found that blue laser irradiation reduced ATP levels and cell viability in mouse skin by increasing oxidative stress through the production of reactive oxygen species.
research Antiaging effects of equol: A unique antiandrogenic isoflavone metabolite and its influence in stimulating collagen deposition in human dermal monolayer fibroblasts
Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.
research 1429 Proteomic analysis of cultured dermal papilla, dermal sheath and dermal fibroblast cells from female scalp highlights alterations in the cell populations with increasing age
In this study, researchers found that proteomic changes with age were significantly more pronounced in dermal papilla cells compared to dermal sheath and interfollicular dermal fibroblasts in the female scalp.