June 2026 in “ACS Nano Medicine” This study designed fibronectin nanogel microneedles, reporting their potential to enhance tissue repair by improving collagen organization, reducing inflammation, and promoting angiogenesis in both photoaged and diabetic wound models.
March 2023 in “Chinese Journal of Dermatology” Protecting hair and scalp from sunlight may help prevent hair loss.
29 citations
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December 2011 in “British Journal of Dermatology” The researchers reported that a novel leave-on treatment containing caffeine, niacinamide, panthenol, dimethicone, and an acrylate polymer significantly increased the diameter and improved the mechanical properties of scalp hair fibers, suggesting it may help mitigate thinning hair.
February 2024 in “Australasian journal of dermatology” This study found that in atrophic acne scars, inflammation infiltrates the pilosebaceous unit over time, affecting resident stem cells and hindering the normal regeneration of the epidermis and adnexal structures, leading to scarring.
3 citations
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February 2019 in “Animal biotechnology” In this study, the PLP2 gene was found to promote secondary hair follicle development in Liaoning cashmere goats, with its expression negatively regulated by melatonin and potentially affecting follicle development via the BMP pathway.
50 citations
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March 2001 in “Clinics in dermatology” This paper reviews the complex anatomy and development of human hair and emphasizes the need to understand these processes for interpreting drug incorporation into hair, with no new clinical results reported.
This review highlights the potential of plant-derived natural compounds as biocompatible and biodegradable materials in dermal and transdermal delivery systems, emphasizing their unexplored benefits and detailing recent advances in isolation techniques and drug delivery technologies.
53 citations
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October 2003 in “Developmental Biology” This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.
262 citations
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May 2017 in “Nanomedicine” This review examines recent advancements in electrospun nanofibers for wound healing applications, but reports no new experimental results, highlighting their potential in sutures, dressings, and skin regeneration.
88 citations
,
April 2012 in “Journal of Investigative Dermatology” This study suggests that TRPV3 may play a key role in dry skin-related itch, indicating potential for TRPV3 antagonists in treating pruritus resistant to histamine H1R antagonists.
39 citations
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June 2012 in “Journal of Structural Biology” Disulfide bonds are crucial for hair structure during keratinization.
32 citations
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June 2013 in “Journal of Investigative Dermatology” This study found that reducing HDAC1 activity in the skin of mice led to defects in hair follicle structure and pigmentation, highlighting HDAC's role in skin and hair maintenance.
27 citations
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May 2017 in “Marine Drugs” This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.
December 2025 in “Animals” In this study on fine-wool sheep, researchers found that overexpressing the TGFBR1 gene decreased proliferation of dermal papilla cells by influencing multiple signaling pathways, suggesting TGFBR1 as a negative regulator in hair follicle development.
April 2024 in “Frontiers in endocrinology (Lausanne)” In this meta-analysis, researchers found that melatonin did not affect primary hair follicles or litter size in goats but was positively correlated with secondary follicle growth, suggesting potential relevance for studying hair growth mechanisms and human alopecia.
This study found that expression and variants of the KRT84 gene are associated with important wool traits in Gansu Alpine Fine-wool sheep, suggesting its potential use as a genetic marker for wool trait selection.
This study used quantitative methods to identify new geometric and mechanical parameters of curly and kinky/coily hair, aiming to improve classification and develop better personal care products for these hair types.
This study suggests that Grateloupia elliptica extract may promote hair growth by activating wnt/β-catenin signaling and fostering dermal papilla cell proliferation.
January 2016 in “Korean Journal of Pharmacognosy” This study found that Grateloupia elliptica extract may promote hair growth by activating wnt/b-catenin signaling and enhancing dermal papilla cell proliferation in rat and mouse models.
83 citations
,
May 2011 in “Experimental Dermatology” In this study, researchers identified nine new sheep keratin genes, highlighting species-specific differences in the expression and compartmentalization of wool-related keratin genes compared to humans.
January 2015 in “Chinese Veterinary Science” This study observed distinct changes in the ultrastructure of Hexi cashmere goat hair follicles throughout the year, highlighting stages with specific cellular and structural characteristics.
39 citations
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January 2020 in “Frontiers in Genetics” This study found that stage-specific epigenetic changes, particularly involving the gene PDGFC, may affect wool fiber development in Zhongwei goats, potentially serving as a biomarker for fur goat selection.
March 2026 in “Scientific Data” This study mapped the genome-wide epigenetic landscape in secondary hair follicle stem cells of goats, revealing distinct histone modification signatures associated with cashmere fiber cycling during different stages of hair growth.
Among Super Merino and Small-Tailed Han sheep, this study identified differentially expressed long non-coding RNAs and mRNAs linked to hair follicle growth and fiber traits, suggesting their potential roles in regulating these important wool characteristics through RNA sequencing and gene enrichment analyses.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
254 citations
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January 2007 in “Chemical Society Reviews” This review discusses the hierarchical structure and chemical properties of hair fibers and offers insights for chemists and biochemists, but reports no new experimental findings.
32 citations
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May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
28 citations
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November 2018 in “Journal of structural biology” This study found statistically significant patterns in hair morphology and ultrastructure linked to biogeographic ancestry among European, African, and East Asian populations.
25 citations
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August 2017 in “Animal Biotechnology” This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.
23 citations
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January 2018 in “BMC genomics” This study found that vimentin expression in the hair follicles of Inner Mongolian Cashmere goats is highest during the growth stage and localized to the outer root sheath, suggesting a role in hair cycle regulation.