January 2025 in “BMC Genomics” In this study, researchers identified thousands of mRNA, lncRNA, circRNA, and miRNA transcripts involved in different hair follicle stages of Rex rabbits and highlighted significant gene expression changes and pathway enrichments, providing insights into the regulatory mechanisms of hair development in these animals.
December 2024 in “International Journal of Molecular Sciences” This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.
November 2023 in “Advanced functional materials” This study suggests that inorganic magnesium silicate sprays can improve burn wound repair and promote regeneration of skin appendages, showing superior results compared to commercial wound healing products in animal models.
June 2023 in “Research Square (Research Square)” This study found that polycaprolactone (PCL) in facial fillers led to more cell proliferation and vascular activity than hyaluronic acid (HA) in Wistar rats, suggesting enhanced tissue regeneration effects with PCL.
May 2023 in “Pharma innovation” In this study conducted at LFC, Apollo College of Veterinary Medicine in Jaipur, and on local farms, 20 cattle calves with ringworm infection fully recovered after treatment with a combination of 2% povidone iodine and Whitefield ointment applied for 15 days.
August 2019 in “Research Square (Research Square)” This study explored how long non-coding RNA mediates the effects of FGF5 on the hair follicle development and villus growth of Liaoning cashmere goats.
This study observed that melatonin significantly increases FGF5 expression in cashmere goat skin, which may influence hair growth-related gene interactions differently than in other animals.
10 citations
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November 2016 in “International Journal of Cosmetic Science” This study proposed the existence of a membrane-like structure between the cuticle and cortex in human hair, which may provide strong protection against external stimuli.
211 citations
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February 2009 in “European journal of pharmaceutics and biopharmaceutics” This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.
182 citations
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June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
98 citations
,
May 2016 in “Genes” This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.
77 citations
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April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
60 citations
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September 2015 in “Expert Review of Clinical Immunology” This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.
34 citations
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April 2012 in “Molecular Biology Reports” This study isolated a thermophilic bacterial strain, Bacillus cereus, from soil that produces an extracellular protease; the enzyme effectively removed non-leather structures from animal pelts and was compatible with commercial detergents.
31 citations
,
September 2008 in “International Journal of Andrology” This review examined studies on erectile dysfunction and 5 alpha-reductase inhibitors, concluding that these drugs do not significantly cause erectile dysfunction and emphasizing testosterone's importance over dihydrotestosterone in erectile function.
23 citations
,
January 2021 in “Scientific Reports” In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.
21 citations
,
April 1990 in “Journal of comparative neurology” This study found that the spinal projection of afferents innervating slowly adapting mechanoreceptors had a greater rostrocaudal extent and number of boutons compared to those innervating rapidly adapting mechanoreceptors.
20 citations
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May 2023 in “Cancer Nanotechnology” The researchers reported that their novel formulation of pterostilbene-loaded ethoniosomes with folic acid coating effectively targeted lung cancer cells in vitro and demonstrated promising results in animal models, indicating potential for future targeted chemotherapy applications.
20 citations
,
September 2019 in “South African Journal of Botany” This study found that Teucrium polium L. subsp. geyrii Maire extract demonstrated a large safety margin in acute and subacute toxicity tests on mice and significantly enhanced wound healing in rats, especially with callus extract, by improving cell proliferation and wound contraction.
18 citations
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August 2018 in “The FASEB journal” This study found that Hoxc13-/- rabbits exhibit complete hair loss on the head and dorsum, providing a potential model for understanding human ECTD-9 and related dermatological conditions.
17 citations
,
October 2023 in “Molecules” In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.
13 citations
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January 2024 in “Journal of Nanobiotechnology” This research reported that a newly developed adhesive wound dressing (SIS/PAA/LAP) demonstrated higher tissue adhesion and burst strength compared to conventional products, and improved tissue repair outcomes in animal models, suggesting potential for enhanced wound healing applications.
12 citations
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November 2003 in “Journal of the American Academy of Dermatology” This study found hair regrowth in the majority of AA-affected mice and rats treated with diphencyprone, suggesting its potential utility for understanding human alopecia areata and the drug's therapeutic action.
8 citations
,
December 2020 in “The FASEB Journal” Blocking adenosine A2B receptor may prevent or treat hearing loss.
4 citations
,
December 2024 in “Applied Sciences” This study analyzed the physico-chemical properties of rosehip seeds, revealing their rich nutritional content, including high levels of dietary fiber, essential fatty acids, minerals, and antioxidants, suggesting their potential application as high-value ingredients in nutraceuticals, pharmaceuticals, and cosmeceuticals.
3 citations
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January 2012 in “Elsevier eBooks” Burn scars form abnormally due to changes in wound healing, and more research is needed to improve treatments.
2 citations
,
February 2024 in “Pharmaceutics” This review highlights that while chitosan-based wound dressings with silver nanoparticles show promise for treating infected wounds due to enhanced antimicrobial activity, further studies are needed to address their in vivo toxicity and evaluate their efficacy in infectious animal models.
2 citations
,
May 2023 in “Frontiers in Bioengineering and Biotechnology” This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.
2 citations
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October 2007 in “Kafrelsheikh Veterinary Medical Journal” This study examined the morphological features of buffalo lips, finding that their structure includes distinct layers of skin, muscle, connective tissue, and glands.
2 citations
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June 2006 in “Experimental dermatology” This article discusses the development of skin patterns during embryogenesis and postnatal life, linking them to genetic, environmental, and mathematical factors, but presents no new empirical findings.