10 citations
,
August 2020 in “Journal of Bioscience and Bioengineering” This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.
8 citations
,
November 2019 in “Tissue Engineering Part A” In this study, collagen scaffolds functionalized with heparin and growth factors significantly enhanced long-term skin regeneration and growth in a sheep model of fetal skin defect, suggesting potential for prenatal spina bifida treatment.
8 citations
,
July 2019 in “Cell Proliferation” In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.
In this study, researchers observed that during zebrafish fin regeneration, osteoblast Erk activity, influenced by Fgf receptor signaling, forms gradients scaling with amputation length, which predicts regenerative tissue growth and skeletal structure size.
7 citations
,
March 2022 in “International Journal of Molecular Sciences” This study found that FGF21 suppresses inflammation induced by C. acnes in both human skin cells and mouse models, suggesting potential use in acne treatment.
7 citations
,
April 2013 in “Journal of Cellular Biochemistry” This study found that mice lacking CD61 had significantly shorter lower incisors compared to wild-type mice, suggesting CD61 is crucial for proper tooth growth and pre-ameloblast proliferation.
5 citations
,
March 2023 in “Journal of Cosmetic Dermatology” This study reports that Plantago asiatica L. extract may promote hair growth by enhancing growth factor production and activating specific signaling pathways in hair follicle dermal papilla cells.
5 citations
,
November 2022 in “Genetics selection evolution” This study found that low-coverage whole-genome sequencing followed by imputation effectively identifies genetic variants associated with wool traits in Angora rabbits, offering a cost-efficient method for genetic research and breeding.
5 citations
,
April 2022 in “Genes” In Angora rabbits, overexpression of miR-129-5p was found to induce apoptosis and inhibit proliferation of dermal papilla cells, highlighting its role in hair follicle development by targeting HOXC13.
5 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This study introduced a simple and reliable in vitro assay capable of large-scale simultaneous screening of hair growth-promoting compounds using a 3D co-culture system of human dermal papilla and outer root sheath cells.
5 citations
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September 2018 in “Journal of Investigative Dermatology” Keratinocyte cytokines and genetic variations influence the development of moles and skin pigmentation.
4 citations
,
May 2022 in “International journal of molecular sciences” This study found that heat-killed Enterococcus faecalis EF-2001 promoted hair regrowth in mice, likely by increasing the expression of growth factors and marker genes.
4 citations
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April 2018 in “Biotechnology Letters” Human growth factor 20 can boost mouse whisker growth.
3 citations
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December 2024 in “Journal of Animal Physiology and Animal Nutrition” In this study, researchers found that reducing FGF20 expression in dermal papilla cells of fine-wool sheep impedes the growth and differentiation of hair follicle stem cells, providing insights into wool trait improvement and regenerative medicine applications.
3 citations
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May 2019 in “Journal of Cosmetic Dermatology” This study suggests that the dipeptide Pro-Ile has FGF18-like activity, can penetrate model human epidermis, and may have potential as a cosmetic ingredient for skin and hair regulation.
2 citations
,
July 2023 in “Animals” In this study, researchers investigated a regulatory network in cashmere goat embryos and found that fibroblast growth factor 10, alongside non-coding RNAs, significantly influences hair follicle cell proliferation, offering insights into the biology of hair follicles in cashmere goats.
2 citations
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May 2022 in “Stem cell research & therapy” This study found that hair follicle stem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.
2 citations
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February 2022 in “Human Gene Therapy” This study found that upregulated miR-149 restricted hair follicle stem cell differentiation and hair growth by inhibiting the MAPK1/ERK2 pathway, which affects FGF2 and c-MYC expression.
2 citations
,
November 2019 in “FEBS open bio” This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
2 citations
,
September 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that dermal condensates are specified before hair follicle niche formation and require FGF20 and Wnt signaling for precursor specification, advancing understanding of niche formation and function during development.
2 citations
,
March 2011 in “Veterinary Dermatology” This study identified fibroblast growth factor 18 in various components of canine hair follicles and other tissues, but found no significant differences in its presence across seasons, body regions, or sexes in beagle dogs.
1 citations
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October 2022 in “Research Square (Research Square)” This study found that melatonin treatment in Cashmere goat kids enhances the density of secondary hair follicles and improves Cashmere quality by regulating the MAPK pathway and reducing cell apoptosis.
1 citations
,
October 2022 in “Annals of Translational Medicine” This study found that cucurbitacin cream reduced FGF18 levels and accelerated hair follicle transition to the anagen phase in mice, suggesting its potential as a treatment for hair regeneration.
1 citations
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March 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study examined wool traits in Angora rabbits using low-coverage whole genome sequencing, identifying six QTLs and a gene, FGF10, linked to fiber growth and diameter, suggesting a cost-effective approach for complex trait analysis in genomic breeding.
1 citations
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February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that a specific fragment of AIMP1 secreted by hair follicle stem cells can stimulate dermal papilla cells and promote hair regrowth.
1 citations
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November 2021 in “Biomedicines” This review elaborates on the concept of cutaneous mosaicism and its link to acneiform conditions, but it reports no new clinical results.
The researchers reported that PEG-FGF2 conjugates, particularly Compound 6, significantly enhanced stability, proliferation, migration, and wound healing activity compared to native FGF2, despite some reduction in bioactivity near crucial binding domains.
1 citations
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November 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that in mice, knockout of Rac1 and Rac3 in keratinocytes led to reduced white adipose tissue and revealed Rac-dependent paracrine pathways affecting pre-adipocyte differentiation.
1 citations
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September 2016 in “Journal of Dermatological Science” This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.
1 citations
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April 2008 in “Pigment Cell & Melanoma Research” This study suggests that Foxn1 expression in keratinocytes influences pigmentation in mice, highlighting differences in the molecular mechanisms between mouse and human pigmentation processes.