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GlossaryFibroblast Growth Factor 10 (FGF10)

protein crucial for skin and hair follicle development

Fibroblast Growth Factor 10 (FGF10) is a protein that plays a crucial role in the development and repair of tissues, including skin and hair follicles. It is involved in cell growth, differentiation, and wound healing, making it important for maintaining healthy skin and promoting hair growth.

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research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations, July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

Investigation of Antioxidant Activity of Cynanchi Wilfordii Radix and Inhibitory Effect of 5α-Reductase mRNA in Human Dermal Papilla Cells

research Investigation of Antioxidant Activity of Cynanchi Wilfordii Radix and Inhibitory Effect of 5α-Reductase mRNA in Human Dermal Papilla Cells

December 2017 in “Dong-ui saengni byeongni hakoeji”

Cynanchi Wilfordii Radix has strong antioxidant effects and may help treat male hair loss.

research A Signature of Genes Including FGF11 Reveals Aberrant Fibroblast Activation and Immune Infiltration in Keloid Tissue

2 citations, August 2022 in “Emergency medicine international”

Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

2 citations, May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis Through the Production of Growth Factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

research Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station

14 citations, March 2016 in “PloS one”

Spaceflight changes how genes work in astronauts' hair follicles, possibly affecting hair growth.

Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

research Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

May 2024 in “Journal of cosmetic dermatology”

Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

research KLF4 Maintains Hair Follicle Stem Cell Quiescence

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

KLF4 is important for keeping hair follicle stem cells inactive.

research An Underlying Mechanism of Hair Loss in Acrodermatitis Enteropathica

August 2016 in “Journal of Investigative Dermatology”

Zinc deficiency disrupts hair growth and cycle, but zinc supplements can fix this.

research Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep

November 2023

Researchers found genes in sheep that may affect hair growth and wool quality.

research CDermo-1 Misexpression Induces Dense Dermis, Feathers, and Scales

29 citations, December 2004 in “Developmental biology”

cDermo-1 causes dense skin, feathers, and scales in chickens.

research Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration

May 2023 in “Journal of Investigative Dermatology”

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

10 citations, December 2021 in “Frontiers in cell and developmental biology”

The research identified genes that explain why some sheep have curly wool and others have straight wool.

research Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist

6 citations, February 2023 in “Journal of nanobiotechnology”

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

research The Hedgehog-GLI1 Pathway Is Important for Fibroproliferative Properties in Keloids and as a Candidate Therapeutic Target

December 2023 in “Communications biology”

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

research Therapeutic Potential of Stem Cells in Follicle Regeneration

45 citations, August 2018 in “Stem Cells International”

Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations, February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research A Transient Dermal Niche and Dual Epidermal Programs Underlie Sweat Gland Development

April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Sweat gland development involves two unique skin cell programs and a temporary skin environment.

research An Overview of the Role of Carboxytherapy in Dermatology

4 citations, March 2023 in “Journal of Cosmetic Dermatology”

Carboxytherapy is a safe and effective treatment for improving skin appearance and treating various skin conditions, with mild side effects.

research Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells

42 citations, February 2018 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.

The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

research The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

23 citations, September 2015 in “PLOS ONE”

Mesenchymal stem cells, especially injected into the skin, heal wounds faster and better than chitosan gel or other treatments.

research Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes

1 citations, November 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

Signals from skin cells controlled by Rac proteins help turn certain precursor cells into white fat cells.

research Protection Against Chemotherapy-Induced Alopecia

97 citations, September 2006 in “Pharmaceutical Research”

No treatment fully prevents hair loss from chemotherapy yet.

research Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid

42 citations, June 2019 in “Aging”

3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.

Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

research Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

5 citations, January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.