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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Dermoscopy helps diagnose and manage alopecia areata by showing specific hair changes.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Fat cells in the skin help start healing and form important repair cells after injury.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.

To diagnose hair loss, use a systematic approach including history, exams, and tests.

Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

Trichoscopy is a quick, cost-effective tool for diagnosing different hair loss conditions.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.