37 citations
,
January 2016 in “Drug design, development and therapy” This review discusses the use of tofacitinib as a treatment for plaque psoriasis, highlighting its efficacy and safety in clinical trials, but notes unresolved questions regarding long-term safety.
36 citations
,
May 2025 in “Antioxidants” This study found that lipid peroxidation products play a clear role in the pathogenesis of skin diseases like psoriasis, vitiligo, and alopecia, but their role in diseases like melanoma and atopic dermatitis remains unclear.
36 citations
,
August 2016 in “The Plant cell” This study found that downregulating PI3K in common bean severely impaired symbiosis with beneficial microorganisms, indicating an essential role for autophagy-related processes in these mutualistic interactions.
33 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” This study found that finasteride treatment significantly reduced hirsutism scores in women with idiopathic hirsutism over 6 months and was well tolerated.
28 citations
,
June 2010 in “Pediatric dermatology” This review discusses short anagen syndrome, highlighting its symptom of abnormally short scalp hair without associated systemic diseases, and notes that hair length often improves spontaneously after puberty without treatment.
27 citations
,
April 2008 in “Neuroscience Letters” Olanzapine reduces stress-related anxiety in rats when given acutely.
27 citations
,
January 2001 in “Hormone Research in Paediatrics” This study found that a lower maintenance dose of flutamide (125 mg/day) effectively maintained the reduction in hirsutism achieved with an initial higher dose (250 mg/day) in women, without additional side effects.
25 citations
,
June 2017 in “Journal of Investigative Dermatology” This study found that in a transgenic mouse model, β-HPV infection led to increased skin thickness and proliferation of specific keratinocyte stem cells, which may contribute to squamous cell carcinoma development.
24 citations
,
May 2015 in “Schizophrenia Research” This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.
23 citations
,
June 2021 in “Lasers in Medical Science” In this study, blue light therapy at a specific wavelength increased hair density and shaft width in 90% of patients with androgenetic alopecia after 10 weeks.
23 citations
,
June 2019 in “Bioanalysis” This study found that monitoring endogenous steroid metabolites in serum may improve the detection of testosterone doping by highlighting promising biomarkers.
23 citations
,
June 2014 in “Journal of Pharmaceutical Sciences” This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.
21 citations
,
February 2021 in “Frontiers in Endocrinology” This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.
20 citations
,
October 2018 in “Clinical Drug Investigation” This study observed that men receiving dutasteride for benign prostatic hyperplasia did not show significant differences in neuropsychological assessments compared to a control group not on dutasteride.
20 citations
,
January 2014 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study suggests that applying a suspension of adipose-derived cells during hair transplantation may enhance wound healing and promote continued hair growth shortly after the procedure.
18 citations
,
October 2022 in “Biomedicines” This review presents clinical and preclinical evidence supporting innovative regenerative approaches to treat vitiligo, as existing treatments lack a specific cure and predictable long-term repigmentation outcomes.
18 citations
,
January 2010 in “Dermatology Research and Practice” This case report describes a 30-year-old Brazilian male who developed vitiligo lesions following diphencyprone therapy for alopecia areata.
16 citations
,
December 2015 in “Journal of Investigative Dermatology” This study found significant gene expression abnormalities in hair follicles affected by alopecia areata, suggesting persistent changes that may predispose to future relapses even after hair regrowth.
16 citations
,
January 2002 in “Dermatology” This study found that the parietal/occipital hair density ratio decreases significantly only when baldness is visibly present, making it no better than the Hamilton/Norwood scale for assessing baldness severity.
14 citations
,
May 2019 in “Experimental Dermatology” In this study, adipose tissue secretome was shown to enhance oxidative stress resistance and promote cell proliferation in vitiligo cells, suggesting a potential natural treatment approach.
14 citations
,
January 2015 in “Skin appendage disorders” This case report details two women with female pattern hair loss who experienced severe scalp allergic contact dermatitis from minoxidil, one due to the active ingredient and the other due to the vehicle.
14 citations
,
June 2014 in “Journal of Pharmaceutical Sciences” This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.
12 citations
,
July 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review evaluates the hormonal, metabolic, and clinical aspects of a male equivalent PCOS syndrome in men and highlights areas where further research is needed, reporting no new empirical findings.
11 citations
,
September 2015 in “Medical Principles and Practice” This study reported that hair and scalp disorders accounted for a significant portion of pediatric dermatology visits, with a diverse range of conditions observed among the children.
11 citations
,
January 2015 in “Dermatology” This study found multiple factors, both inherited and acquired, that may lead to bradykinin-mediated angio-oedema, proposing a new classification based on bradykinin production and catabolism imbalance.
10 citations
,
October 2024 in “Dermatology Practical & Conceptual” This study found that dupilumab's effects on alopecia areata varied depending on patients' immune profiles, with Th2-skewed females seeing improvements and Th1-driven males experiencing worsening.
10 citations
,
July 2014 in “Veterinary dermatology” This study found that deslorelin may promote hair regrowth in intact male dogs with hair cycle arrest, but had no effect on neutered females.
10 citations
,
April 2008 This article explores the potential of chitin nanofibrils as a bioactive polymer for skin applications by examining their hydrophilic properties and effects on cell behavior, but presents no new experimental results.
9 citations
,
February 2020 in “International Journal of Endocrinology” This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.
9 citations
,
March 1991 in “American Journal of Contact Dermatitis” In this study, 67 patients developed contact dermatitis from using minoxidil for hair loss, with patch tests suggesting it is a frequent sensitizer among topical drugs.