Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review highlights the unique scarless wound healing abilities of fetuses and discusses potential applications to adult wound healing, reporting no new experimental findings.

This study observed that combined treatment with thyroxine and hydrocortisone increased lipid accretion and fat cell development in hypophysectomized fetal pigs, suggesting a key role of these hormones in fetal adipogenesis.

This study concludes that fetal skin cells can significantly enhance wound healing and reduce scarring when used to treat severe burns and various wounds in children.

This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.

This study found that a serum-free DMEM-F12 medium with 45% oxygen best supports in vitro development and differentiation of human fetal skin, closely mimicking the in vivo state.

This study presents a new mouse model for investigating chronic graft-versus-host disease, highlighting the role of human thymic tissue in developing multiorgan fibrosis driven by human immune cells.

In this study, the researchers found distinct patterns of TGF-beta 1 and IGF-II expression in pig fetal subcutaneous tissue, suggesting specific regulatory roles in developing adipocytes and muscle tissue.

This study concluded that placental mesenchymal stem cells from aborted fetal tissue may serve as an in vitro model for studying spontaneous abortion mechanisms and potential regenerative therapies due to their abnormal gene expression and differentiation capabilities.

Fetuin-A helps wounds heal without scars by promoting cell movement.

In this study, fetal stem cells were identified in adult human hair follicles long after childbirth, indicating potential for autologous therapies due to their pluripotent characteristics.

This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.

This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.

This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.

This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

This study describes how manipulating the actin cytoskeleton, particularly through the gelsolin family proteins, may enhance regenerative healing in mammals, suggesting potential therapeutic pathways for improved wound repair.

This article proposes several potential approaches for scar prevention and therapy, including anti-transforming growth factor-β strategies and tissue-engineered skin, but reports no new clinical results.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

This study found that using 3D cultures and fetal tissue extracts significantly improved the outcomes of stem cell treatments for regenerative medicine, including hair follicle formation and chronic wound healing.

This study found that EDA and EDAR are expressed throughout cashmere goat fetal development and play a critical role in hair follicle formation by influencing gene expression in fibroblasts and epithelial cells.

This study used TMT-based quantitative proteomics to analyze the development of secondary hair follicles in fetal sheep, revealing increased follicle density and key proteins involved, such as COL1A1 and THBS4, indicating their potential role in wool quality traits.

This article discusses the unique regenerative healing process in fetal skin that can occur without scarring, highlighting potential therapeutic targets to reduce fibrosis in postnatal wound healing.

Vitamin D3 affects cell differentiation in specific skin areas.

This historical review discusses the ancient Egyptians' advanced wound-healing techniques, including the use of honey and moldy bread, and reports no new clinical results.

In this study, synchrotron fibre diffraction identified changes in dermal collagen microfibrillar radius with age, with lower radii observed in individuals with insulin-dependent diabetes mellitus.

In this study on tolerant rats, maternal and developmental toxicity from levo-alpha-acetyhnethadol hydrochloride were observed at all doses, without specific fetal toxicity or teratogenic effects.

In this study, epithelial cell-derived exosomes promoted fibroblast migration and inhibited their proliferation, suggesting a role in dermal condensate formation and hair follicle morphogenesis in cashmere goats.

This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.

This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.

This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.

In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.