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    Glossary Scarless Healing

    process where tissue repairs without forming scar tissue

    Scarless healing, also known as regenerative healing, refers to the process by which the body repairs damaged tissues without forming scar tissue. This type of healing restores the tissue to its original structure and function, unlike typical wound healing that often results in fibrous scar tissue. Scarless healing is observed in certain animals and in human fetal development, and it is a significant area of research for improving wound care and regenerative medicine.

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    1. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    2. Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing Biological Procedures Online · 2025
    3. Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing Journal of Investigative Dermatology · 2007 · 21 citations
    4. Scarless wound healing – a literature review Romanian Journal of Pediatrics · 2019 · 2 citations
    5. Confocal Microscopic Analysis of Scarless Repair in the Fetal Rat Plastic & Reconstructive Surgery · 2002 · 99 citations
    6. Differential Expression of Fibromodulin, a Transforming Growth Factor-β Modulator, in Fetal Skin Development and Scarless Repair American Journal of Pathology · 2000 · 168 citations
    7. Chapter 6 Fetal Skin Wound Healing Advances in Clinical Chemistry · 2009 · 89 citations
    8. Role of boundary conditions in an experimental model of epithelial wound healing The Year book of surgery · 2007
    9. Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerating Healing Preprints.org · 2026
    10. Wound healing 2012
    11. Regeneration, Wound Healing and Cancer 2017 · 1 citations
    12. Animal models for the study of fetal tissue repair Journal of Surgical Research · 1991 · 69 citations
    13. Hydrogen peroxide disrupts scarless fetal wound repair Wound Repair and Regeneration · 2005 · 41 citations
    14. An In Vivo Mouse Excisional Wound Model of Scarless Healing Plastic and Reconstructive Surgery · 2006 · 58 citations
    15. Minimizing Skin Scarring through Biomaterial Design Journal of Functional Biomaterials · 2017 · 23 citations
    16. New potential antiscarring approaches Wound Repair and Regeneration · 2011 · 10 citations
    17. The developing immune network in human prenatal skin Immunology · 2020 · 11 citations
    18. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization American Journal of Pathology · 2003 · 109 citations
    19. A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus Frontiers in Cell and Developmental Biology · 2021 · 42 citations
    20. Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Scientific reports · 2024
    21. Modulating embryonic signaling pathways paves the way for regeneration in wound healing Frontiers in physiology · 2024
    22. Wound Healing: A Paradigm for Regeneration Mayo Clinic Proceedings · 2013 · 64 citations
    23. Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype Signal Transduction and Targeted Therapy · 2017 · 35 citations
    24. Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Research Square (Research Square) · 2024
    25. Mammalian Fetal Organ Regeneration 2005 · 32 citations
    26. Procesul de vindecare fără cicatrizare – review de literatură Romanian Journal of Pediatrics · 2019
    27. Skin biology Elsevier eBooks · 2019 · 5 citations
    28. Wound healing in development Birth Defects Research · 2012 · 29 citations
    29. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021 · 74 citations
    30. Quoi de neuf en recherche dermatologique ? Annales de Dermatologie et de Vénéréologie · 2008