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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The document concludes that managing side effects of MS therapies is crucial for treatment success and patient adherence.

The new FDA labeling rules provide more detailed drug safety information for pregnant and breastfeeding women, but more data is needed on the risks of many dermatologic drugs.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

The dog's skin condition improved after removing a tumor that was causing hormone imbalances.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Most pregnancies with SLE resulted in intrauterine growth restriction (IUGR).

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Pregnant women with Systemic Lupus Erythematosus have a higher risk of blood clotting problems.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Bariatric surgery patients need careful before and after surgery care for safety and long-term health.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

PFS affects some women, steroids easily bought online, hypogonadism info unreliable, low testosterone linked to CVD.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Muscles can make their own androgens, which may help muscle growth.

Cepharanthine has many medicinal uses but needs improvement for better effectiveness.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

Pregnancy can trigger severe rosacea, which may be treated with antibiotics and steroids, but there's no clear treatment guideline.

Certain KIR genes in Indian SLE patients are linked to disease severity and could be biomarkers.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Adding fetal calf serum helps Merkel cells survive and change shape.

Adding fetal calf serum to the medium kept Merkel cells alive and changed their shape.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

LAAM caused developmental toxicity in tolerant rats without causing birth defects.

CD8+ T cells play a key role in graft-versus-host disease in certain mice models.