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LAAM caused developmental toxicity in tolerant rats without causing birth defects.

Accurate diagnosis and timely, tailored treatments improve outcomes in obstetrics and gynecology.

Some skin medications are safe for pregnant women, but others pose risks or should not be used.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Women with Systemic Lupus Erythematosus should have closely monitored pregnancies and avoid certain medications to improve their pregnancy outcomes.

Some skin medications can harm male fertility, but they don't seem to cause birth defects from father's exposure.

Pregnancy can cause various skin changes, including pigmentation, acne, and stretch marks, and may affect preexisting skin conditions.

EZH2 levels decrease as fetuses develop and are higher in adult skin, which may affect skin growth and repair.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

Lifestyle changes and clomiphene are first-line treatments for infertility in women with PCOS, with other options available if these fail.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

A man had a large, rare cyst in his mouth removed after 10 years, which fixed his swallowing and breathing problems.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Minoxidil use during pregnancy may cause fetal harm.

Minoxidil use during pregnancy can cause excessive hair growth and multiple birth defects in the baby.

Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

Exposure to the hair loss drug finasteride during pregnancy can cause genital anomalies in male babies, but not in female babies. It's best to avoid this drug in women who could potentially become pregnant.

Netherton syndrome can cause severe dehydration, infections, and growth issues in infants.

Gene mutations can cause problems in male genital development.

The document concludes that early diagnosis and treatment are crucial for children with hair loss to prevent permanent damage, although not all conditions can be effectively treated.

New genes and pathways are important for testosterone production and male sexual development.

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

A Japanese patient with IFAP syndrome had a severe MBTPS2 gene mutation but showed milder symptoms than previously observed cases.

Use some skin medications with caution during pregnancy; avoid strong steroids, certain eczema treatments, and systemic retinoids, but many topical treatments and nasal sprays are safe.