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Cysteine-rich keratins evolved independently in mammals, reptiles, and birds for hard skin structures like hair, claws, and feathers.

Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.

Different hair types in mammals are linked to variations in specific protein genes, with changes influenced by their living environments.

The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.

The Megsin-Cre transgene is a new tool for genetic manipulation in the skin and upper digestive tract.

Using neurohormones to control keratin can lead to new skin disease treatments.

A new hydrogel with micronized amnion helps achieve better, scar-free skin healing.

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Different fish use the same genes to regrow teeth.

Different light affects cell functions and can help treat skin conditions.

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Natural products and phytochemicals may help with hair regrowth, but more research is needed.

Future hair cosmetics will be safer and more effective.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Two teenage brothers had a rare, treatment-resistant form of female-pattern hair loss with unusual scalp changes.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

BMP signaling is essential for the development of touch domes.

Rex rabbits' hair follicles develop dynamically in the first 8 weeks, with key genes and proteins changing over time.

Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

A new hair loss treatment is being developed using reprogrammed stem cells to grow new hair follicles.