This report describes a case of Goltz syndrome in a 12-year-old Saudi girl, highlighting the variability in symptoms and the importance of documenting such rare syndromes.
March 2022 in “Research Square (Research Square)” This study found that 4-aminopyridine significantly improved skin wound healing by enhancing wound closure, tissue regeneration, and cellular interactions involved in repair processes.
November 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that 4-aminopyridine, a potassium channel blocker, greatly improves skin wound healing by accelerating wound closure, enhancing tissue regeneration, and promoting hair follicle neogenesis.
April 2023 in “Klinicheskaya dermatologiya i venerologiya” This study highlights that while oral Minoxidil at doses ineffective for hypertension may promote hair regrowth, uncertainties remain about its long-term outcomes and effects in patients with underlying conditions.
November 2022 in “Journal of Education, Health and Sport” This review discusses various pharmacotherapies for androgenetic alopecia, concluding that combination therapies may offer more effective treatment, though more research on alternative preparations is needed.
89 citations
,
November 2014 in “International Journal of Nanomedicine” This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.
54 citations
,
January 2023 in “Signal Transduction and Targeted Therapy” This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
54 citations
,
September 2000 in “Archives of dermatology” In this study, 95% of respondents reported severe hair breakage or loss after using the Rio Hair Naturalizer System, with many experiencing significant and lasting hair loss.
52 citations
,
January 2022 in “Current Research in Pharmacology and Drug Discovery” This review highlights ongoing efforts in drug repurposing and development of new therapeutics against COVID-19, emphasizing the promise of these strategies in addressing the challenges posed by SARS-CoV-2 mutations and post-infection complications.
50 citations
,
December 2011 in “Skin Research and Technology” In this study, the researchers reported that their novel algorithm for hair restoration in dermoscopy images achieved high accuracy and texture preservation, outperforming other techniques in diagnostic accuracy and texture quality measures.
50 citations
,
January 2007 in “PubMed” This review discusses female pattern hair loss, highlighting that while oral antiandrogens and topical minoxidil can arrest progression, early diagnosis and treatment are crucial, and stresses the need for ongoing therapy.
44 citations
,
November 2022 in “Frontiers in Immunology” This review discusses the role of toll-like receptors in cancer treatment, providing an overview of pre-clinical studies and clinical trials on TLR-targeted therapies and noting the challenges and future prospects.
39 citations
,
April 2020 in “IntechOpen eBooks” The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.
34 citations
,
April 2001 in “PubMed” This study found that eflornithine HCl 13.9% cream reduces unwanted facial hair growth in women, with effects seen in up to 60% of participants over 4-8 weeks, with mostly minor skin irritation reported.
31 citations
,
October 2002 in “Dermatologic Surgery” This article reviews expert opinions on combining pharmacologic treatments like minoxidil with hair transplantation, reporting improved hair density and regrowth in patients with partially functioning follicles.
30 citations
,
March 2007 in “Expert opinion on drug safety” This review discusses recommendations for managing cetuximab-induced rash in metastatic colorectal cancer treatment and highlights the lack of standardized treatment plans based on clinical evidence.
26 citations
,
February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
22 citations
,
March 2000 in “Clinics in Dermatology” This study developed a method using HPLC with UV-DAD and ESI-MS detection to identify prohibited substances like minoxidil and hormones in cosmetic products advertised online for hair loss and skin conditions.
20 citations
,
January 2000 in “Dermatologic Clinics” This article discusses recent advancements in treatments for psoriasis, including new drug approvals and innovative therapeutic approaches, but reports no new clinical results.
19 citations
,
July 2023 in “Neuroscience & Biobehavioral Reviews” This review explores the role of neurosteroids in affective disorders, highlighting existing research on their impact on mood and discussing emerging evidence that endogenous neurosteroids may influence baseline emotional states.
19 citations
,
October 2016 in “Nutrition in clinical practice” This article provides guidelines by ASPEN for managing parenteral nutrition shortages but reports no new clinical findings.
19 citations
,
September 2011 in “Seminars in Cutaneous Medicine and Surgery” This review discusses home-use laser and light skin devices for various dermatological purposes and reports no new clinical findings; the authors highlight the need for dermatologists to evaluate these devices' clinical value.
14 citations
,
October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
14 citations
,
September 2024 in “Arthritis & Rheumatology” In this study, a patient with clinically amyopathic dermatomyositis experienced persistent skin issues despite treatment, highlighting questions about type I interferon's role in skin disorders and potential IFN-targeted therapies for cutaneous lupus erythematosus and dermatomyositis.
12 citations
,
January 2019 in “Regenerative Medicine” In this commentary, the authors discuss the challenges and proposals for responsibly translating regenerative therapies into clinical practice, emphasizing the need for patient education, quality control, and real-world evidence to validate these therapies and address ongoing misinformation in the field.
11 citations
,
March 2021 in “Dermatology and therapy” This study developed the Alopecia Areata Patient Priority Outcome (AAPPO), a new tool designed to measure and capture the symptoms and impacts of alopecia areata that matter most to patients.
11 citations
,
January 2012 in “PubMed” This case report suggests that topical bimatoprost may promote eyebrow hair growth, as observed in a patient with eyebrow hypotrichosis, but lacks broader published scientific evidence.
9 citations
,
July 2014 in “PubMed” This review examines the scientific evidence behind alternative treatments for female pattern hair loss and androgenetic alopecia, such as biotin, caffeine, and melatonin, but provides no new clinical results.
8 citations
,
July 2024 in “Children” This study discusses how emerging biologics and small molecule therapies could enhance disease management and pediatric health outcomes for chronic skin conditions, suggesting their potential inclusion in treatment guidelines pending ongoing clinical trial successes.
8 citations
,
August 2020 in “Experimental dermatology” This study observed that platelet-rich plasma samples from female patients show significant variability in growth factor secretion, which may influence the inconsistent clinical response in alopecia treatment.