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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Some medicinal plants can help heal wounds and may lead to new treatments.

Myrtle has various health benefits and potential for medicine development.

Latanoprost can make eyelashes longer, thicker, and darker.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Hair follicles may soon be used more for targeted and systemic drug delivery.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Probiotic bacteria improved skin and hair health in aged mice.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Preoperative pain assessment, regional anesthesia, and vitamin C can help prevent CRPS after surgery.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

Ozone reacts more with unwashed hair, producing compounds due to scalp oils, which could lower ozone exposure but increase exposure to reaction products.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Antioxidants can benefit skin health but should be used carefully to avoid negative effects.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Triparanol therapy can cause hair loss and skin dryness without inflammation or damage to hair follicles or skin structures.

New genes and pathways are important for testosterone production and male sexual development.