93 citations
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April 2003 in “Proceedings of the National Academy of Sciences of the United States of America” This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.
70 citations
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February 2019 in “The journal of immunology/The Journal of immunology” This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.
40 citations
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July 2019 in “Journal of Investigative Dermatology” In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.
40 citations
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June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.
28 citations
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January 2018 in “Biochemical Society Transactions” This review explores the role of fatty acids and bioactive lipid mediators in skin health and suggests targeting this metabolic network to control inflammation and improve skin conditions, but it reports no new findings.
19 citations
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March 1961 in “Nature” A fatty acid/protein complex in human hair helps protect it from damage.
18 citations
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August 2014 in “Lipids” This study found that unsaturated fatty acids are more abundant in the cortex of human hair than on its surface, and steryl glycoside-like lipids may help bind the cuticle to the cortex.
5 citations
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January 2021 in “Journal of Saudi Chemical Society” This study analyzed watercress oil and confirmed its phytochemical profile, UV absorption properties, and potential efficacy for hair growth, supporting traditional hot oil applications.
4 citations
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September 1977 in “Lipids” This study observed that gerbils on a fat-deficient diet had altered fatty acid composition in various organs and exhibited hair loss, reduced testis development, and often lower body weight compared to those on a fat-supplemented diet.
4 citations
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November 1970 in “PubMed” This study found that mustard oil and unsaturated fatty acids completely suppressed dermatophyte growth and prevented hair penetration at concentrations of 1% and above in Sabouraud's dextrose agar medium.
3 citations
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January 2017 in “Journal of cosmetology & trichology” This study reports that a nutritional complex may improve hair density and quality, with in vitro findings demonstrating inhibition of 5α-reductase, and participants noting reduced hair loss and greasiness.
1 citations
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May 2023 in “Frontiers in endocrinology” The researchers reported that the novel MBTPS2 variant p.Glu172Asp found in a male proband is likely pathogenic, consistent with osteogenesis imperfecta symptoms and molecular signatures, including disrupted fatty acid metabolism and collagen production.
1 citations
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June 2019 in “Current developments in nutrition” This case study reports that pancreatic enzyme replacement and fatty acid supplementation improved symptoms of fat malabsorption and essential fatty acid deficiency in a patient with EDS-4.
1 citations
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July 2024 in “International Journal of Cosmetic Science” This study found that para rubber seed oil, rich in specific fatty acids, effectively protected human epidermal coculture cells from UV-induced damage by reducing inflammatory markers and enzymes linked to photoaging, indicating its potential as a safe and innovative photoaging treatment.
August 2026 in “Nature Communications” This study found that early mitochondrial reprogramming, specifically through fatty acid oxidation fueling oxidative phosphorylation, is crucial for initiating differentiation in epidermal stem cells, highlighting a potential therapeutic target for differentiation defects in skin disorders.
July 2026 in “Journal of Investigative Dermatology” This study found that omega-6 and saturated fatty acid-enriched diets promote weight gain and certain skin changes regardless of gut microbiota, while omega-3 diets limit adiposity and affect skin in a microbiota-dependent way in mice, highlighting a diet–microbiota–lipid relationship in skin health.
This study found that periodic red light exposure in aged mice increased histone acetylation and activated metabolic processes in keratinocytes, mitigating cellular aging through enhanced fatty acid oxidation and altered gene expression related to lipid metabolism.
This study found that periodic red light exposure increased histone acetylation and activated metabolic processes in aged mice, leading to enhanced fatty acid oxidation and the mitigation of cellular aging by influencing gene expression and metabolic regulation.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.
July 2025 in “Food Science & Nutrition” This study found that vitamin D supplementation in diets of Rex rabbits improved hair follicle development and fatty acid metabolism, with 1400–2100 IU/kg proving most effective for hair density and 2800 IU/kg increasing hair length.
June 2024 in “ChemBioChem” This study's simulations suggest that replenishing free 18‐MEA could restore damaged hair surface properties, highlighting the importance of optimal fatty acid spacing for maintaining hair integrity.
January 2024 in “The Egyptian Journal of Hospital Medicine” This study found that A-FABP serum levels were significantly higher in male patients with androgenetic alopecia compared to controls, and the authors concluded that A-FABP could serve as a biomarker for early detection of this condition.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that CCCA in women of African descent is associated with molecular changes, including dysregulation of fatty acid metabolism and fibrosis pathways, suggesting potential targets for new treatments.
April 2019 in “Journal of Investigative Dermatology” This study found that lichen planopilaris is associated with three core molecular pathways, which may inform new therapeutic strategies for scarring alopecia, including unique pathways like ABC transporters specific to LPP.
January 2016 in “Institutional Repositories DataBase (IRDB)” This study examined the expression of fatty acid transporters and binding proteins in mouse sebaceous glands and found that CD36 did not affect the localization of other related molecules.
This study suggests that 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester from African Yam bean seeds may inhibit the human 5α-reductase II enzyme, potentially helping manage BPH, although further studies are needed.
This study used molecular dynamics simulations to illustrate the complex molecular behavior of the hair surface F-layer, highlighting how fatty acids interact with 18-MEA under different conditions.
April 2016 in “Journal of Investigative Dermatology” This study found that both topical tretinoin and oral isotretinoin altered the free fatty acid profile of sebum in acne patients, affecting bacterial growth differently for S. epidermidis and S. aureus.
April 2026 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, supplementing adult Bichon Frises with 600 mg/kg Omega-3 PUFAs significantly improved their skin health, hair quality, feeding behavior, and metabolic health, compared to a control diet, over six weeks.
August 2013 in “Fertility and Sterility” This study found that women with PCOS have higher follicular fluid levels of testosterone and IL-6, despite similar NEFA levels to non-PCOS women, suggesting increased lipotoxicity impact on androgenesis in PCOS.