This study found that serum irisin levels were significantly lower in patients with androgenetic alopecia compared to healthy controls, but no significant relationship was detected between serum irisin levels and insulin resistance markers like BMI, fasting insulin, or HOMA-IR.
July 2026 in “International Journal of Science and Research (IJSR)” In this study, women with PCOS were found to have higher BMI, insulin resistance, and homocysteine levels, which are key predictors of the condition.
October 2020 in “Benha Journal of Applied Sciences” This study observed that patients with acne vulgaris had significantly lower serum vaspin levels and higher insulin resistance, suggesting a potential role of vaspin in the disease's pathogenesis.
5 citations
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June 2018 in “Journal of Diabetes, Metabolic Disorders & Control” This study found that women with polycystic ovary syndrome have higher triglyceride and fasting glucose levels in obese individuals and higher total cholesterol levels in non-obese individuals compared to healthy women.
September 2020 in “Benha Journal of Applied Sciences” In this study, researchers found that serum Myostatin levels and HOMA-IR were significantly higher in patients with androgenic alopecia compared to controls, suggesting they could be indicators of disease susceptibility and severity.
2 citations
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October 2021 in “Clinical Epidemiology and Global Health” The researchers reported a high incidence of hyperuricemia in women with PCOS, with positive correlations to testosterone, SHBG, HOMA-IR, and LDL levels, but negative correlations to HbA1C, FPG, and FSI.
28 citations
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March 2009 in “Clinical and Experimental Dermatology” This article discusses the potential relationship between androgenic alopecia and insulin resistance but presents no new clinical findings, calling for further research on the topic.
This study reported that women with acanthosis nigricans and insulin resistance often exhibit signs of hyperandrogenism, including hirsutism, and have elevated fasting plasma insulin compared to controls.
43 citations
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May 1988 in “British Journal of Dermatology” This study reported that patients with acanthosis nigricans and insulin resistance exhibited higher insulin levels and were associated with increased insulin resistance correlating with serum testosterone levels.
In this case-control study, researchers found that serum apelin-12 levels were significantly higher in acne patients and correlated with acne severity, BMI, insulin resistance, and inflammation, suggesting that managing insulin resistance could be important for acne treatment.
February 2013 in “Journal of The American Academy of Dermatology” There is no significant link between insulin resistance and certain hair disorders like idiopathic hirsutism and androgenic alopecia.
February 2026 in “World Journal of Interdisciplinary Innovation Sciences” This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.
39 citations
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August 2001 in “Clinical endocrinology” This study found that lean women with PCOS have a similar degree of tissue insulin resistance as obese women with PCOS, suggesting that insulin resistance may be a primary feature of the syndrome.
October 2022 in “The Egyptian Journal of Hospital Medicine” In this study, serum omentin-1 levels were higher in females with idiopathic hirsutism compared to those with hirsutism and polycystic ovary syndrome, suggesting it may help distinguish between these conditions.
December 2023 in “Benha Journal of Applied Sciences” This study found that male patients with androgenetic alopecia had higher serum levels of Zinc Alpha 2 Glycoprotein than healthy controls, suggesting its potential role in the disease's pathophysiology.
5 citations
,
October 2018 in “Journal of Clinical Laboratory Analysis” This study found that improved testosterone measurement using LC-MS/MS in women with PCOS revealed a stronger correlation between hyperandrogenism and insulin resistance than previously detected.
4 citations
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December 2021 in “Clinical and Experimental Reproductive Medicine” This study found that women with PCOS who had a higher serum estrone-to-estradiol ratio were more likely to exhibit higher fasting insulin and postprandial glucose levels, even after adjusting for BMI and waist-to-hip ratio.
149 citations
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December 2007 in “The Journal of Clinical Endocrinology and Metabolism” Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.
44 citations
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March 2008 in “European journal of endocrinology” This study found that women with PCOS had lower fasting serum ghrelin levels and a reduced ghrelin response to an oral glucose load compared to controls, with an inverse relationship to insulin resistance.
6 citations
,
December 2022 in “Frontiers in Pharmacology” This review examines the potential therapeutic effects and mechanisms of quercetin for treating polycystic ovary syndrome, noting improved clinical parameters in some studies but presenting no new results.
This study found that abnormal carbohydrate metabolism linked to increased serum fasting insulin levels is associated with 20% of women with polycystic ovary syndrome, and these women exhibit more symptoms compared to those with normal insulin levels.
16 citations
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March 2015 in “Wiener Klinische Wochenschrift” Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.
14 citations
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August 2014 in “Applied Physiology, Nutrition, and Metabolism” This study concluded that an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS.
2 citations
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July 2022 in “Indian Journal of Dermatology Venereology and Leprology” This study found that patients with premature greying of hair had significant abnormalities in cardiovascular risk markers, including elevated IL-6 levels, compared to healthy controls.
This study found that metformin significantly improved clinical and hormonal indices in patients with polycystic ovary syndrome compared to pioglitazone, which also effectively controlled some symptoms.
73 citations
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June 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study provides further evidence for a genetic basis of PCOS, showing that polycystic ovarian morphology is a marker of inherited biochemical features in families with PCOS.
1 citations
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January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that hypothyroidism in women with PCOS significantly increased insulin resistance and obesity, which might worsen metabolic issues and impact conditions like hair loss and infertility.
March 2022 in “Benha Journal of Applied Sciences” This study found that serum PGRN levels and HOMA-IR were significantly higher in male AGA patients compared to controls, suggesting a link to insulin resistance and metabolic syndrome.
October 2025 in “The Egyptian Journal of Hospital Medicine” This study found that patients with alopecia areata had lower adiponectin levels and higher leptin levels compared to healthy controls, with leptin levels correlating positively with insulin resistance markers and negatively with HDL cholesterol.
January 2025 in “Indian Journal of Biochemistry and Biophysics” This study found that the uric acid to creatinine ratio had excellent diagnostic ability for polycystic ovary syndrome, with significant associations to metabolic and hematologic changes in PCOS patients.